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Hypothalamic mappin...
Hypothalamic mapping of orexigenic action and Fos-like immunoreactivity following relaxin-3 administration in male Wistar rats.
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- Mc Gowan, BM (author)
- Imperial College London
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- Stanley, SA (author)
- Imperial College London
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- White, NE (author)
- Imperial College London
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- Spångeus, Anna, 1975- (author)
- Imperial College London
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- Patterson, M (author)
- Imperial College London
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- Thompson, EL (author)
- Imperial College London
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- Smith, KL (author)
- Imperial College London
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- Donovan, J (author)
- Imperial College London
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- Gardiner, JV (author)
- Imperial College London
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- Ghatei, MA (author)
- Imperial College London
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- Bloom, SR (author)
- Imperial College London
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(creator_code:org_t)
- American Physiological Society, 2007
- 2007
- English.
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In: American Journal of Physiology. Endocrinology and Metabolism. - : American Physiological Society. - 0193-1849 .- 1522-1555. ; 292, s. 913-919
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The insulin superfamily, characterized by common disulphide bonds, includes not only insulin but also insulin-like peptides such as relaxin-1 and relaxin-3. The actions of relaxin-3 are largely unknown, but recent work suggests a role in regulation of food intake. Relaxin-3 mRNA is highly expressed in the nucleus incertus, which has extensive projections to the hypothalamus, and relaxin immunoreactivity is present in several hypothalamic nuclei. In the rat, relaxin-3 binds and activates both relaxin family peptide receptor 1, which also binds relaxin-1, and a previously orphaned G protein-coupled receptor, RXFP3. These receptors are extensively expressed in the hypothalamus. The aims of these studies were twofold: 1) map the hypothalamic site(s) of the orexigenic action of relaxin-3 and 2) examine the site(s) of neuronal activation following central relaxin-3 administration. After microinjection into hypothalamic sites, human relaxin-3 (H3; 180 pmol) significantly stimulated 0- to 1-h food intake in the supraoptic nucleus (SON), arcuate nucleus (ARC), and the anterior preoptic area (APOA) [SON 0.4 ± 0.2 (vehicle) vs. 2.9 ± 0.5 g (H3), P < 0.001; ARC 0.7 ± 0.3 (vehicle) vs. 2.7 ± 0.2 g (H3), P < 0.05; and APOA 0.8 ± 0.1 (vehicle) vs. 2.2 ± 0.2 g (H3), P < 0.05]. Cumulative food intake was significantly increased 8 h following administration into the SON and 4 h into the APOA. A significant increase in Fos-like immunoreactivity was seen in the SON following central relaxin-3 administration. Relaxin-3 stimulates feeding in several hypothalamic nuclei, and these studies provide additional support for relaxin-3 as an important peptide in appetite regulation.
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- MEDICINE
- MEDICIN
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Mc Gowan, BM
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Stanley, SA
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White, NE
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Spångeus, Anna, ...
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Patterson, M
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Thompson, EL
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show more...
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Smith, KL
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Donovan, J
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Gardiner, JV
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Ghatei, MA
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Bloom, SR
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show less...
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American Journal ...
- By the university
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Linköping University