Search: onr:"swepub:oai:DiVA.org:liu-42547" >
Type 1 diabetes :
Type 1 diabetes : Increased height and weight gains in early childhood
-
- Ljungkrantz, M (author)
- Dept of Pediatrics Blekingesjukhuset, Karlskrona
-
- Ludvigsson, Johnny, 1943- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Pediatrik,Barn- och ungdomskliniken i Linköping
-
- Samuelsson, Ulf, 1951- (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Pediatrik,Barn- och ungdomskliniken i Linköping
-
(creator_code:org_t)
- Hindawi Limited, 2008
- 2008
- English.
-
In: Pediatric Diabetes. - : Hindawi Limited. - 1399-543X .- 1399-5448. ; 9:3 PART 2, s. 50-56
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Objective: The accelerator/beta-cell stress hypothesis regards insulin resistance as one common basis for type 1 and type 2 diabetes and weight increase as an important trigger of type 1 diabetes. To test this hypothesis, we examined children's height and weight gain from birth to the time of diagnosis of type 1 diabetes. Method: Growth charts (n=316) from children 0-16yr old up to the time of diagnosis of type 1 diabetes were compared with growth charts from age- and sex-matched controls. Results: Compared with their controls, children who developed diabetes had experienced more pronounced gain in both weight and height. In the year of diagnosis, they were taller [0.5 vs. 0.36 standard deviation score (SDS), p<0.03] and heavier (0.7 vs. 0.45 SDS, p<0.01). Children who developed diabetes aged 5yr or less gained more weight during the period between their third month and third year of life (p<0.01). Children who were diagnosed between 6 and 10yr of age had gained more in height before they were 5yr old (p<0.05). Regression analysis showed that a high weight or a high body mass index (BMI) at 5yr of age indicated, more than the other measurements, a high risk for diabetes later during childhood, while height and weight at ages less than 5yr did not add any further information on diabetes risk. Conclusions: Rapid growth before 7yr of age and increased BMI in childhood are risk factors for later type 1 diabetes. These findings support the accelerator/beta-cell stress hypothesis. © 2008 The Author Journal compilation © 2008 Blackwell Munksgaard.
Keyword
- age groups
- BMI
- growth
- length
- weight
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database