Sökning: onr:"swepub:oai:DiVA.org:liu-51784" >
Phase II randomized...
-
M Del Campo, JVall Hebron University Hospital
(författare)
Phase II randomized study of trabectedin given as two different every 3 weeks dose schedules (1.5 mg/m(2) 24 h or 1.3 mg/m(2) 3 h) to patients with relapsed, platinum-sensitive, advanced ovarian cancer
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
-
Elsevier BV,2009
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:liu-51784
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-51784URI
-
https://doi.org/10.1093/annonc/mdp198DOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-30046URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Patients and methods: Patients previously treated with less than two or two previous chemotherapy lines were randomized to receive trabectedin 1.5 mg/m(2) 24 h (arm A, n = 54) or 1.3 mg/m(2) 3 h (arm B, n = 53). Objective response rate (ORR) per RECIST was the primary efficacy end point. Toxic effects were graded according to the National Cancer Institute-Common Toxicity Criteria v. 2.0. Results: ORR was 38.9% [95% confidence interval (CI) 25.9% to 53.1%; arm A] and 35.8% (95% CI 23.1% to 50.2%; arm B) (intention-to-treat primary analysis). Median time to progression was 6.2 months (95% CI 5.3-8.6 months; arm A) and 6.8 months (95% CI 4.6-7.4 months; arm B). Frequent severe adverse events were nausea/vomiting (24%, arm A; 15%, arm B) and fatigue (15%, arm A; 10%, arm B). Common severe laboratory abnormalities were transient, noncumulative neutropenia (55%, arm A; 37%, arm B) and transaminase increases (alanine aminotransferase, 55%, arm A; 59%, arm B). Conclusions: Both every-3-weeks trabectedin regimes, 1.5 mg/m(2) 24 h and 1.3 mg/m(2) 3 h, were active and reasonably well tolerated in AOC platinum-sensitive patients. Trabectedin every-3-weeks has promising activity and deserves to be further evaluated in relapsed AOC.
Ämnesord och genrebeteckningar
-
ovarian cancer
-
phase II
-
RECIST
-
response rate
-
trabectedin
-
MEDICINE
-
MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Roszak, AWielkopolska Oncol Centre
(författare)
-
Bidzinski, MMaria Sklodowska Curie Mem Canc Centre
(författare)
-
Ciuleanu, T EIon Chiricuta Canc Institute
(författare)
-
Högberg, ThomasÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US(Swepub:liu)thoho49
(författare)
-
Wojtukiewicz, M ZMed University, Comprehens Canc Centre Bialystok
(författare)
-
Poveda, AValencian Institute Oncol
(författare)
-
Boman, Karin,1946-Umeå universitet,Onkologi,Umeå University Hospital(Swepub:umu)kabo0010
(författare)
-
Westermann, A MUniversity of Amsterdam
(författare)
-
Lebedinsky, CPharmaMar Clin R&D
(författare)
-
Vall Hebron University HospitalWielkopolska Oncol Centre
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:ANNALS OF ONCOLOGY: Elsevier BV20:11, s. 1794-8020923-7534
-
Ingår i:Annals of oncology : official journal of the European Society for Medical Oncology / ESMO: Elsevier BV20:11, s. 1794-8021569-8041
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
M Del Campo, J
-
Roszak, A
-
Bidzinski, M
-
Ciuleanu, T E
-
Högberg, Thomas
-
Wojtukiewicz, M ...
-
visa fler...
-
Poveda, A
-
Boman, Karin, 19 ...
-
Westermann, A M
-
Lebedinsky, C
-
visa färre...
- Artiklar i publikationen
-
ANNALS OF ONCOLO ...
-
Annals of oncolo ...
- Av lärosätet
-
Linköpings universitet
-
Umeå universitet