onr:"swepub:oai:DiVA.org:liu-54512"
Search: onr:"swepub:oai:DiVA.org:liu-54512" > Ion-specific thermo...
- 1 of 1
- Previous record
- Next record
- To hitlist
Ion-specific thermodynamical properties of aqueous proteins
-
- Lima, Eduardo R A (author)
- University Fed Rio de Janeiro
-
- Biscaia Jr, Evaristo C (author)
- University Fed Rio de Janeiro
-
- Boström, Mathias (author)
- Linköpings universitet,Teoretisk Fysik,Tekniska högskolan
- show more...
- show less...
- (creator_code:org_t)
- 2010
- 2010
- English.
- In: ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS. - 0001-3765. ; 82:1, s. 109-126
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Ion-specific interactions between two colloidal particles are calculated using a modified Poisson-Boltzmann (PB) equation and Monte Carlo (MC) simulations. PB equations present good results of ionic concentration profiles around a macroion, especially for salt solutions containing monovalent ions. These equations include not only electrostatic interactions, but also dispersion potentials originated from polarizabilities of ions and proteins. This enables us to predict ion-specific properties of colloidal systems. We compared results obtained from the modified PB equation with those from MC simulations and integral equations. Phase diagrams and osmotic second virial coefficients are also presented for different salt solutions at different pH and ionic strengths, in agreement with the experimental results observed Hofmeister effects. In order to include the water structure and hydration effect, we have used an effective interaction obtained from molecular dynamics of each ion and a hydrophobic surface combined with PB equation. The method has been proved to be efficient and suitable for describing phenomena where the water structure close to the interface plays an essential role. Important thermodynamic properties related to protein aggregation, essential in biotechnology and pharmaceutical industries, can be obtained from the method shown here.
Keyword
- colloid stability
- Hofmeister series
- potential of mean force
- proteins
- TECHNOLOGY
- TEKNIKVETENSKAP
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Lima, Eduardo R ...
- Biscaia Jr, Evar ...
- Boström, Mathias
- Tavares, Frederi ...
- Articles in the publication
- ANAIS DA ACADEMI ...
- By the university
- Linköping University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
