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Prevalence of fecal...
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Chabok, AbbasUppsala universitet,Kolorektalkirurgi,Centrum för klinisk forskning, Västerås
(författare)
Prevalence of fecal carriage of antibiotic-resistant bacteria in patients with acute surgical abdominal infections
- Artikel/kapitelEngelska2010
Förlag, utgivningsår, omfång ...
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2010-06-03
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Informa Healthcare,2010
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-60498
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-60498URI
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https://doi.org/10.3109/00365521.2010.495417DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-133102URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Objective. Antibiotic resistance is increasing worldwide. The aims of the current study were to determine the fecal carriage of antibiotic-resistant bacteria and antibiotic treatment in surgical patients admitted to hospital due to acute intra-abdominal infections. Materials and methods. Eight Swedish surgical units participated in this prospective multicenter investigation. Rectal swabs were obtained on admission to hospital. Cultures were performed on chromogenic agar and antibiotic susceptibility testing was performed using the disk diffusion method. Extended-spectrum beta-lactamase (ESBL)phenotype was confirmed by Etest. Results. Rectal samples were obtained and analyzed from 208 patients with intra-abdominal surgical infections. Surgery was performed in 134 patients (65%). Cephalosporins were the most frequently used empirical antibiotic therapy. The highest rates of resistance among Enterobacteriaceae were detected for ampicillin (54%), tetracycline (26%), cefuroxime (26%) and trimethoprim-sulfamethoxazole (20%). The prevalence of decreased susceptibility (I + R) for the other antibiotics tested was for ciprofloxacin 20%, piperacillin-tazobactam 17%, cefotaxime 14%, ertapenem 12%, gentamicin 3% and imipenem 0%. ESBL-producing Enterobacteriaceae were found in samples from 10 patients (5%). Three patients had five E. coli isolates producing AmpC enzymes. Conclusions. This study shows a high rate of resistance among Enterobacteriaceae against antibiotics which are commonly used in Sweden and should have implications for the future choice of antibiotics for surgical patients.
Ämnesord och genrebeteckningar
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Abdominal infection
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antibiotics
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antibiotic resistance
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bacteria
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resistance
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Påhlman, LarsUppsala universitet,Kolorektalkirurgi(Swepub:uu)larspahl
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Nilsson, LennartLinköpings universitet,Klinisk mikrobiologi,Hälsouniversitetet(Swepub:liu)lenni43
(författare)
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Lindberg, ChristianLinköpings universitet,Infektionsmedicin,Hälsouniversitetet(Swepub:liu)chrli20
(författare)
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Hanberger, HåkanÖstergötlands Läns Landsting,Linköpings universitet,Infektionsmedicin,Hälsouniversitetet,Infektionskliniken i Östergötland(Swepub:liu)hakha84
(författare)
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Uppsala universitetKolorektalkirurgi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY: Informa Healthcare45:10, s. 1203-12100036-55211502-7708
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