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Assaying cardiac bi...
Assaying cardiac biomarkers for toxicity testing using biosensing and cardiomyocytes derived from human embryonic stem cells
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- Andersson, Henrik (author)
- Linköpings universitet,Teknisk biologi,Tekniska fakulteten
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- Steel, Daniella (author)
- Cellartis AB, Gothenburg, Sweden
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- Asp, Julia, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,University of Gothenburg
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- Dahlenborg, Kerstin (author)
- Linköpings universitet,Teknisk biologi,Tekniska högskolan
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- Jonsson, Marianne, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,University of Gothenburg
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- Jeppsson, Anders, 1960 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrens University Hospital
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- Lindahl, Anders, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin,Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine,University of Gothenburg
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- Kågedal, Bertil (author)
- Östergötlands Läns Landsting,Linköpings universitet,Klinisk kemi,Hälsouniversitetet
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- Sartipy, Peter (author)
- Cellartis AB, Gothenburg, Sweden
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- Mandenius, Carl-Fredrik (author)
- Linköpings universitet,Teknisk biologi,Tekniska högskolan
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(creator_code:org_t)
- Elsevier Science B.V., Amsterdam. 2010
- 2010
- English.
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In: JOURNAL OF BIOTECHNOLOGY. - : Elsevier Science B.V., Amsterdam.. - 0168-1656 .- 1873-4863. ; 150:1, s. 175-181
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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Abstract
Subject headings
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- Human embryonic stem cell (hESC) derived cardiomyocytes are in the present study being used for testing drug-induced cardiotoxicity in a biosensor set-up. The design of an in vitro testing alternative provides a novel opportunity to surpass previous methods based on rodent cells or cell lines due to its significantly higher toxicological relevance. In this report we demonstrate how hESC-derived cardiomyocytes release detectable levels of two clinically decisive cardiac biomarkers, cardiac troponin T and fatty acid binding protein 3, when the cardiac cells are exposed to the well-known cardioactive drug compound. doxorubicin. The release is monitored by the immuno-biosensor technique surface plasmon resonance, particularly appropriate due to its capacity for parallel and high-throughput analysis in complex media.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- In vitro toxicity testing
- hESC-derived cardiomyocytes
- Doxorubicin
- Biosensors
- Surface plasmon resonance. SPR
- TECHNOLOGY
- TEKNIKVETENSKAP
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Andersson, Henri ...
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Steel, Daniella
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Asp, Julia, 1973
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Dahlenborg, Kers ...
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Jonsson, Mariann ...
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Jeppsson, Anders ...
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show more...
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Lindahl, Anders, ...
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Kågedal, Bertil
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Sartipy, Peter
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Mandenius, Carl- ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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JOURNAL OF BIOTE ...
- By the university
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Linköping University
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University of Gothenburg