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Increased Levels of...
Increased Levels of Kynurenine and Kynurenic Acid in the CSF of Patients With Schizophrenia
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- Linderholm, Klas R (author)
- Department of Physiology and Pharmacology, Karolinska Institutet
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- Skogh, Elisabeth (author)
- Östergötlands Läns Landsting,Linköpings universitet,Psykiatri,Hälsouniversitetet,Psykiatriska kliniken
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- Olsson, Sara K (author)
- Department of Physiology and Pharmacology, Karolinska Institutet
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- Dahl, Marja-Liisa (author)
- Uppsala universitet,Karolinska Institutet,Department of Medical Sciences, Clinical Pharmacology, Uppsala University,Institutionen för medicinska vetenskaper
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- Holtze, Maria (author)
- Department of Physiology and Pharmacology, Karolinska Institutet
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- Engberg, Göran (author)
- Karolinska Institutet,Department of Physiology and Pharmacology, Karolinska Institutet
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- Samuelsson, Martin (author)
- Östergötlands Läns Landsting,Linköpings universitet,Psykiatri,Hälsouniversitetet,Psykiatriska kliniken
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- Erhardt, Sophie (author)
- Karolinska Institutet,Department of Physiology and Pharmacology, Karolinska Institutet
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(creator_code:org_t)
- 2010-08-20
- 2012
- English.
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In: Schizophrenia Bulletin. - : Oxford University Press. - 0586-7614 .- 1745-1701. ; 38:3, s. 426-432
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Abstract
Subject headings
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- Background: The kynurenic acid (KYNA) hypothesis for schizophrenia is partly based on studies showing increased brain levels of KYNA in patients. KYNA is an endogenous metabolite of tryptophan (TRP) produced in astrocytes and antagonizes N-methyl-D-aspartate and alpha7* nicotinic receptors. Methods: The formation of KYNA is determined by the availability of substrate, and hence, we analyzed KYNA and its precursors, kynurenine (KYN) and TRP, in the cerebrospinal fluid (CSF) of patients with schizophrenia. CSF from male patients with schizophrenia on olanzapine treatment (n = 16) was compared with healthy male volunteers (n = 29). Results: KYN and KYNA concentrations were higher in patients with schizophrenia (60.7 +/- 4.37nM and 2.03 +/- 0.23nM, respectively) compared with healthy volunteers (28.6 +/- 1.44nM and 1.36 +/- 0.08nM, respectively), whereas TRP did not differ between the groups. In all subjects, KYN positively correlated to KYNA. Conclusion: Our results demonstrate increased levels of CSF KYN and KYNA in patients with schizophrenia and further support the hypothesis that KYNA is involved in the pathophysiology of schizophrenia.
Keyword
- psychosis
- kynurenate
- olanzapine
- cerebrospinal fluid
- tryptophan
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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