Sökning: onr:"swepub:oai:DiVA.org:liu-66972" > Increased Levels of...
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000 | 03997naa a2200517 4500 | |
001 | oai:DiVA.org:liu-66972 | |
003 | SwePub | |
008 | 110323s2012 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:124517087 | |
009 | oai:DiVA.org:uu-174716 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-669722 URI |
024 | 7 | a https://doi.org/10.1093/schbul/sbq0862 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1245170872 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1747162 URI |
040 | a (SwePub)liud (SwePub)kid (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Linderholm, Klas Ru Department of Physiology and Pharmacology, Karolinska Institutet4 aut |
245 | 1 0 | a Increased Levels of Kynurenine and Kynurenic Acid in the CSF of Patients With Schizophrenia |
264 | c 2010-08-20 | |
264 | 1 | b Oxford University Press,c 2012 |
338 | a print2 rdacarrier | |
520 | a Background: The kynurenic acid (KYNA) hypothesis for schizophrenia is partly based on studies showing increased brain levels of KYNA in patients. KYNA is an endogenous metabolite of tryptophan (TRP) produced in astrocytes and antagonizes N-methyl-D-aspartate and alpha7* nicotinic receptors. Methods: The formation of KYNA is determined by the availability of substrate, and hence, we analyzed KYNA and its precursors, kynurenine (KYN) and TRP, in the cerebrospinal fluid (CSF) of patients with schizophrenia. CSF from male patients with schizophrenia on olanzapine treatment (n = 16) was compared with healthy male volunteers (n = 29). Results: KYN and KYNA concentrations were higher in patients with schizophrenia (60.7 +/- 4.37nM and 2.03 +/- 0.23nM, respectively) compared with healthy volunteers (28.6 +/- 1.44nM and 1.36 +/- 0.08nM, respectively), whereas TRP did not differ between the groups. In all subjects, KYN positively correlated to KYNA. Conclusion: Our results demonstrate increased levels of CSF KYN and KYNA in patients with schizophrenia and further support the hypothesis that KYNA is involved in the pathophysiology of schizophrenia. | |
653 | a psychosis | |
653 | a kynurenate | |
653 | a olanzapine | |
653 | a cerebrospinal fluid | |
653 | a tryptophan | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Skogh, Elisabethu Östergötlands Läns Landsting,Linköpings universitet,Psykiatri,Hälsouniversitetet,Psykiatriska kliniken4 aut0 (Swepub:liu)elisk66 |
700 | 1 | a Olsson, Sara Ku Department of Physiology and Pharmacology, Karolinska Institutet4 aut |
700 | 1 | a Dahl, Marja-Liisau Uppsala universitet,Karolinska Institutet,Department of Medical Sciences, Clinical Pharmacology, Uppsala University,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)madah516 |
700 | 1 | a Holtze, Mariau Department of Physiology and Pharmacology, Karolinska Institutet4 aut |
700 | 1 | a Engberg, Göranu Karolinska Institutet,Department of Physiology and Pharmacology, Karolinska Institutet4 aut |
700 | 1 | a Samuelsson, Martinu Östergötlands Läns Landsting,Linköpings universitet,Psykiatri,Hälsouniversitetet,Psykiatriska kliniken4 aut0 (Swepub:liu)marsa78 |
700 | 1 | a Erhardt, Sophieu Karolinska Institutet,Department of Physiology and Pharmacology, Karolinska Institutet4 aut |
710 | 2 | a Department of Physiology and Pharmacology, Karolinska Institutetb Psykiatri4 org |
773 | 0 | t Schizophrenia Bulletind : Oxford University Pressg 38:3, s. 426-432q 38:3<426-432x 0586-7614x 1745-1701 |
856 | 4 | u https://academic.oup.com/schizophreniabulletin/article-pdf/38/3/426/5264402/sbq086.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-66972 |
856 | 4 8 | u https://doi.org/10.1093/schbul/sbq086 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:124517087 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-174716 |
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