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Hematopoietic Stem ...
Hematopoietic Stem Cell Transplantation Rates and Long-Term Survival in Acute Myeloid and Lymphoblastic Leukemia Real-World Population-Based Data From the Swedish Acute Leukemia Registry 1997-2006
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- Juliusson, Gunnar (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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- Karlsson, Karin (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital
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- Lazarevic, Vladimir (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital
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- Wahlin, Anders (författare)
- Umeå universitet,Onkologi,Umeå University
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- Brune, Mats (författare)
- Sahlgrens University Hospital
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- Antunovic, Petar (författare)
- Linköpings universitet,Hälsouniversitetet,Kirurgi
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- Derolf, Asa (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Hägglund, Hans (författare)
- Uppsala universitet,Hematologi,Karolinska University Hospital
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- Karbach, Holger (författare)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Lehmann, Soren (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Mollgard, Lars (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Stockelberg, Dick (författare)
- Sahlgrens University Hospital
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- Hallböök, Helene (författare)
- Uppsala universitet,Medicin,Hematologi,Academic Hospital, Uppsala
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- Höglund, Martin (författare)
- Uppsala universitet,Medicin,Hematologi,Academic Hospital, Uppsala
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(creator_code:org_t)
- 2011-03-08
- 2011
- Engelska.
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Ingår i: Cancer. - Philadelphia : Wiley-Blackwell. - 0008-543X .- 1097-0142. ; 117:18, s. 4238-4246
- Relaterad länk:
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https://onlinelibrar...
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Allogeneic stem cell transplantation (alloSCT) reduces relapse rates in acute leukemia, but outcome is hampered by toxicity. Population-based data avoid patient selection and may therefore substitute for lack of randomized trials. METHODS: We evaluated alloSCT rates within the Swedish Acute Leukemia Registry, including 3899 adult patients diagnosed from 1997 through 2006 with a coverage of 98% and a median follow-up of 6.2 years. RESULTS: AlloSCT rates and survival decreased rapidly with age andgt;55 years. The 8-year overall survival (OS) was 65% in patients andlt;30 years and 38% in patients andlt;60 years and was similar for acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). Among 1073 patients andlt;60 years, alloSCT was performed in 42% and 49% of patients with AML and ALL, respectively. Two-thirds of the alloSCTs were performed in first complete remission, and half used unrelated donors, the same in AML and ALL. Regional differences in management and outcome were found: 60% of AML patients andlt;40 years received alloSCT in all parts of Sweden, but two-thirds of AML patients 40-59 years had alloSCT in one region compared with one-third in other regions (Pandlt;.001), with improved 8-year OS among all AML patients in this age cohort (51% vs 30%; P = .005). CONCLUSIONS: More Swedish AML patients received alloSCT, and long-term survival was better than in recently published large international studies, despite our lack of selection bias. There was no correlation between alloSCT rate and survival in ALL. In adult AML patients andlt;60 years of age, a high alloSCT rate was associated with better long-term survival, but there was no such correlation in ALL.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- acute myeloid leukaemia
- acute lymphoblastic leukaemia
- allogeneic stem cell transplantation
- population based
- performance status
- nonrelapse mortality
- survival
- MEDICINE
- MEDICIN
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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Cancer
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Till lärosätets databas
- Av författaren/redakt...
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Juliusson, Gunna ...
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Karlsson, Karin
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Lazarevic, Vladi ...
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Wahlin, Anders
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Brune, Mats
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Antunovic, Petar
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visa fler...
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Derolf, Asa
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Hägglund, Hans
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Karbach, Holger
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Lehmann, Soren
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Mollgard, Lars
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Stockelberg, Dic ...
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Hallböök, Helene
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Höglund, Martin
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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Cancer
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Linköpings universitet
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Umeå universitet
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Lunds universitet
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Karolinska Institutet
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Uppsala universitet