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A bisphosphonate-co...
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Abtahi, JahanÖstergötlands Läns Landsting,Linköpings universitet,Ortopedi,Hälsouniversitetet,Käkkliniken US
(author)
A bisphosphonate-coating improves the fixation of metal implants in human bone. A randomized trial of dental implants
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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Elsevier,2012
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:liu-77527
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-77527URI
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https://doi.org/10.1016/j.bone.2012.02.001DOI
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https://gup.ub.gu.se/publication/160765URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Swedish Research Council|VR 2009-6725|
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Many surgical procedures use metal implants in bone. The clinical results depend on the strength of the bone holding these implants. Our objective was to show that a drug released from the implant surface can improve parameters reflecting the quality or amount of this bone. Sixteen patients received paired dental titanium implants in the maxilla, in a randomized, double-blinded fashion. One implant in each pair was coated with a thin fibrinogen layer containing 2 bisphosphonates. The other implant was untreated. Fixation was evaluated by measurement of resonance frequency (implant stability quotient; ISQ) serving as a proxy for stiffness of the implant-bone construct. Increase in ISQ at 6 months of follow-up was the primary variable. None of the patients had any complications. The resonance frequency increased 6.9 ISQ units more for the coated implants (p = 0.0001; Cohens d = 1.3). The average difference in increase in ISQ and the effect size, suggested a clinically relevant improvement. X-ray showed less bone resorption at the margin of the implant both at 2 months (p = 0.012) and at 6 months (p = 0.012). In conclusion, a thin, bisphosphonate-eluting fibrinogen coating might improve the fixation of metal implants in human bone. This might lead to new possibilities for orthopedic surgery in osteoporotic bone and for dental implants.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Tengvall, PenttiGothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials(Swepub:gu)xtenpe
(author)
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Aspenberg, PerLinköpings universitet,Östergötlands Läns Landsting,Ortopedkliniken i Linköping,Ortopedi,Hälsouniversitetet(Swepub:liu)peras36
(author)
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Linköpings universitetOrtopedi
(creator_code:org_t)
Related titles
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In:Bone: Elsevier50:5, s. 1148-11518756-32821873-2763
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