Sökning: onr:"swepub:oai:DiVA.org:liu-77753" > MyD88 in hematopoie...
Fältnamn | Indikatorer | Metadata |
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000 | 03481nam a2200301 4500 | |
001 | oai:DiVA.org:liu-77753 | |
003 | SwePub | |
008 | 120528| | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-777532 URI |
040 | a (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a vet2 swepub-contenttype |
072 | 7 | a ovr2 swepub-publicationtype |
100 | 1 | a Ruud, Johanu Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)johru61 |
245 | 1 0 | a MyD88 in hematopoietic cells, but not in cerebrovascular endothelial cells or neural cells, is critical for inflammation- and cancer-induced loss of appetite |
338 | a print2 rdacarrier | |
520 | a Loss of appetite concomitant with reduced food intake is a hallmark of both acute and chronic inflammatory diseases. Yet, despite extensive investigations, the underlying mechanisms remain undefined. Here we addressed this issue using mice lacking MyD88, critical for Tolllike and IL-1 receptor family signaling, generally or in specific cell types. Ubiquitous null deletions conferred complete resistance to bacterial lipopolysaccharide (LPS) induced anorexia, but this resistance was lost when knock-out mice subjected to whole-body irradiation to delete hematopoietic cells were transplanted with wild-type bone-marrow. In line with this observation, mice lacking MyD88 in hematopoietic cells were largely protected against LPS-induced anorexia, whereas mice with abrogated MyD88 signaling in neural cells, being leaner and smaller, developed anorexia of similar magnitude as wild-type littermates. The effect of hematopoietic MyD88-deletion on feeding seemed however partially dissociated from the effect on body weight, since LPS triggered weight loss, although attenuated, in these mutants. Furthermore, MyD88 deficiency in the cerebrovascular endothelium affected neither LPS-induced anorexia nor weight loss. In a model for the cancer anorexia-cachexia syndrome, inactivation of MyD88 in hematopoietic cells strongly impaired the anorexia development and protected against body weight loss. These findings identify hematopoietic cells as a critical nexus for acute inflammatory driven anorexia as well as for chronic anorexia associated with malignant disease. | |
700 | 1 | a Björk Wilhelms, Danielu Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)danbj96 |
700 | 1 | a Nilsson, Annau Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)annni62 |
700 | 1 | a Eskilsson, Annau Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)annes38 |
700 | 1 | a Yan-Juan, Tangu Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)yanta19 |
700 | 1 | a Bäckhed, Fredriku Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy, Sahlgrenska University Hospital, Gothenburg, Sweden4 aut |
700 | 1 | a Lundholm, Kentu Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden4 aut |
700 | 1 | a Engblom, Davidu Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)daven69 |
700 | 1 | a Blomqvist, Andersu Linköpings universitet,Cellbiologi,Hälsouniversitetet4 aut0 (Swepub:liu)andbl47 |
710 | 2 | a Linköpings universitetb Cellbiologi4 org |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-77753 |
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