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Virtual Histology A...
Virtual Histology Assessment of Cardiac Allograft Vasculopathy Following Introduction of Everolimus—Results of a Multicenter Trial
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- Arora, Satish (author)
- Oslo University Hospital Rikshospitalet, Norway,Rigshospitalet, Copenhagen, Denmark
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- Erikstad, I. (author)
- Oslo University Hospital Rikshospitalet, Norway
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- Ueland, T. (author)
- Oslo University Hospital Rikshospitalet, Norway
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- Sigurdardottir, V. (author)
- Sahlgrenska University Hospital, Gothenburg, Sweden
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- Ekmehag, Björn (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital and Lund University, Lund, Sweden
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- Jansson, Kjell (author)
- Östergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken US
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- Eiskjaer, H. (author)
- Östergötlands Läns Landsting,Kardiologiska kliniken US,Skejby University Hospital, Denmark
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- Bøtker, H. E. (author)
- Skejby University Hospital, Denmark
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- Mortensen, S.-A. (author)
- Rigshospitalet, Copenhagen, Denmark
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- Saunamaki, K. (author)
- Rigshospitalet, Copenhagen, Denmark
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- Gude, E. (author)
- Oslo University Hospital Rikshospitalet, Norway
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- Ragnarsson, A. (author)
- Oslo University Hospital Rikshospitalet, Norway
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- Solbu, D. (author)
- Medical Department, Novartis, Norway
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- Gullestad, L (author)
- Oslo University Hospital Rikshospitalet, Norway
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- Jansson, Kristina (author)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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Aukrust, P (author)
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(creator_code:org_t)
- Wiley-Blackwell, 2012
- 2012
- English.
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In: American Journal of Transplantation. - : Wiley-Blackwell. - 1600-6135 .- 1600-6143. ; 12:10, s. 2700-2709
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- In this 12-month multicenter Scandinavian study, 78 maintenance heart transplant (HTx) recipients randomized to everolimus with reduced calcineurin inhibitor (CNI) exposure or continued standard CNI-therapy underwent matched virtual histology (VH) examination to evaluate morphological progression of cardiac allograft vasculopathy (CAV). Parallel measurement of a range of inflammatory markers was also performed. A similar rate of quantitative CAV progression was observed in the everolimus (n = 30) and standard CNI group (n = 48) (plaque index 1.9 +/- 3.8% and 1.6 +/- 3.9%, respectively; p = 0.65). However, VH analysis revealed a significant increase in calcified (2.4 +/- 4.0 vs. 0.3 +/- 3.1%; p = 0.02) and necrotic component (6.5 +/- 8.5 vs. 1.1 +/- 8.6%; p = 0.01) among everolimus patients compared to controls. The increase in necrotic and calcified components was most prominent in everolimus patients with time since HTx andgt;5.1 years and was accompanied by a significant increase in levels of von Willebrand (vWF) factor (p = 0.04) and vascular cell adhesion molecule (VCAM) (p = 0.03). Conversion to everolimus and reduced CNI is associated with a significant increase in calcified and necrotic intimal components and is more prominent in patients with a longer time since HTx. A significant increase in vWF and VCAM accompanied these qualitative changes and the prognostic implication of these findings requires further investigation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Cardiac allograft vasculopathy
- everolimus
- inflammation
- virtual histology
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Arora, Satish
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Erikstad, I.
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Ueland, T.
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Sigurdardottir, ...
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Ekmehag, Björn
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Jansson, Kjell
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show more...
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Eiskjaer, H.
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Bøtker, H. E.
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Mortensen, S.-A.
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Saunamaki, K.
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Gude, E.
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Ragnarsson, A.
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Solbu, D.
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Gullestad, L
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Jansson, Kristin ...
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Aukrust, P
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
- Articles in the publication
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American Journal ...
- By the university
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Linköping University
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Lund University