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Fibroblast Growth F...
Fibroblast Growth Factor 23, Hepatocyte Growth Factor, Interleukin-6, High-Sensitivity C-Reactive Protein and Soluble Urokinase Plasminogen Activator Receptor. Inflammation Markers in Chronic Haemodialysis Patients?
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- Almroth, Gabriel (author)
- Östergötlands Läns Landsting,Linköpings universitet,Njurmedicin,Hälsouniversitetet,Njurmedicinska kliniken US,Departments of Nephrology, Linköping University Hospital, Linköping, Sweden; Department of Medicine and Health Sciences, Linköping University Hospital, Linköping, Sweden
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- Lönn, Johanna (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,PEAS Institute, Linköping, Sweden,University of Örebro, Sweden
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- Uhlin, Fredrik (author)
- Östergötlands Läns Landsting,Linköpings universitet,Internmedicin,Hälsouniversitetet,Njurmedicinska kliniken US,Departments of Nephrology, Linköping University Hospital, Linköping, Sweden; Department of Medicine and Health Sciences, Linköping University Hospital, Linköping, Sweden
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- Nayeri, Fariba (author)
- Östergötlands Läns Landsting,Linköpings universitet,Infektionsmedicin,Hälsouniversitetet,Infektionskliniken i Östergötland,PEAS Institute, Linköping, Sweden; Division of Infectious diseases, Linköping University Hospital, Linköping, Sweden
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- Brudin, Lars (author)
- Linköpings universitet,Avdelningen för kardiovaskulär medicin,Hälsouniversitetet,Department of Medicine and Health Sciences, Linköping University Hospital, Linköping, Sweden; Department of Physiology, Kalmar County Hospital, Kalmar, Sweden
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- Andersson, B (author)
- Department of Clinical Immunology, Sahlgren’s University Hospital, Gothenburg, Sweden
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- Hahn-Zoric, M (author)
- Department of Clinical Immunology, Sahlgren’s University Hospital, Gothenburg, Sweden
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(creator_code:org_t)
- 2013-08-22
- 2013
- English.
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In: Scandinavian Journal of Immunology. - : Wiley-Blackwell. - 0300-9475 .- 1365-3083. ; 78:3, s. 285-290
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Sera from 84 haemodialysis (HD) patients and 68 healthy blood donors were analysed with commercially available ELISA techniques for fibroblast growth factor 23 (FGF-23), hepatocyte growth factor (HGF), interleukin-6 (Il-6), high-sensitivity C-reactive protein (hs-CRP) and soluble urokinase plasminogen activator receptor (suPAR), to find a possible correlation of FGF-23 and HGF with the earlier recognized inflammatory markers Il-6 and hs-CRP or suPAR. All patients studied had significantly elevated levels of FGF-23, HGF, hs-CRP and suPAR as compared to the controls. Il-6 and hs-CRP correlated for patients (R=0.6) as well as for patients and controls altogether. Ln (natural logarithm) of HGF correlated weakly with Ln Il-6 and Ln CRP (R 0.28-0.37). Ln FGF-23 correlated only with Ln HGF (r=-0.25) in controls. Ln HGF correlated with ln suPAR (r=0.6) in both patients and controls. Although elevated as compared to controls, we found no correlation of FGF-23 with the recognized inflammatory markers Il-6, hs-CRP, nor HGF or the new marker suPAR in HD patients. Ln HGF correlated with Ln Il-6, Ln CRP and Ln suPAR. Although probably involved in vessel disease, FGF-23 and HGF may play other roles than acting in inflammatory vessel disease in HD patients. Further studies are necessary to evaluate the role of these immunological markers in chronic haemodialysis patients with atherosclerosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
- Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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