Reduced oxygenation in diabetic rat kidneys measured by T2* weighted magnetic resonance micro-imaging

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:DiVA.org:liu-99314" > Reduced oxygenation...

1 of 1
Previous record
Next record
To hitlist

Reduced oxygenation in diabetic rat kidneys measured by T2* weighted magnetic resonance micro-imaging

Edlund, Jenny (author): Uppsala universitet,Institutionen för medicinsk cellbiologi

Hansell, Peter (author): Uppsala universitet,Integrativ Fysiologi

Fasching, Angelica (author): Uppsala universitet,Integrativ Fysiologi

Liss, Per (author): Uppsala universitet,Enheten för radiologi

Weis, Jan (author): Uppsala universitet,Enheten för radiologi

Glickson, Jerry D. (author)

Palm, Fredrik (author): Uppsala universitet,Integrativ Fysiologi

show less...

(creator_code:org_t)

Boston, MA : Springer US, 2009
2009
English.
In: Advances in Experimental Medicine and Biology. - Boston, MA : Springer US. - 0065-2598 .- 2214-8019. ; 645, s. 199-204

Related links:: https://urn.kb.se/re...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

By applying invasive techniques for direct measurements of oxygen tension, we have reported decreased kidney oxygenation in experimental diabetes in rats. However, the non-invasive MRI technique utilizing the BOLD effect provides several advantages with the possibility to perform repetitive measurements in the same animals and in human subjects. In this study, we applied a modified single gradient echo micro-imaging sequence to detect the BOLD effect in kidneys of diabetic rats and compared the results to normoglycemic controls. All measurements were performed on inactin-anaesthetized adult male Wistar Furth rats. Diabetes was induced by streptozotocin (45 mg/kg) 14 days prior to MRI-analysis. Sixteen T2*-weighted image records (B0=1.5 T) were performed using radiofrequency spoiled gradient echo sequence with 2.6 ms step increments of TE (TE1=12 ms), while TR (75 ms) and bandwidth per pixel (71.4 Hz) were kept constant. T2* maps were computed by mono-exponential fitting of the pixel intensities. Relaxation rates R2* (1/T2*) in cortex and outer stripe of the outer medulla were similar in both groups (cortex for controls 22.3 +/- 0.4 vs. diabetics 23.1 +/- 1.8 Hz and outer stripe of outer medulla for controls 24.9 +/- 0.4 vs. diabetics 26.4 +/- 1.8 Hz; n=4 in both groups), whereas R2* was increased in the inner stripe of the outer medulla in diabetic rats (diabetics 26.1 +/- 2.4 vs. controls 18.8 +/- 1.4 Hz; n=4, P<0.05). This study demonstrates that experimental diabetes in rats induces decreased oxygenation of the renal outer medulla. Furthermore, the proposed T2*-weighted MR micro-imaging technique is suitable for detection of regional changes in kidney oxygenation in experimental animal models.

Keyword

MEDICINE
MEDICIN

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

Advances in Experimental Medicine and Biology (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Edlund, Jenny; Hansell, Peter; Fasching, Angeli ...; Liss, Per; Weis, Jan; Glickson, Jerry ...; show more...; Palm, Fredrik; show less...

Articles in the publication: Advances in Expe ...

By the university: Linköping University; Uppsala University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se