Search: onr:"swepub:oai:DiVA.org:lnu-73333" >
Acute heart failure...
Acute heart failure following myocardial infarction : complement activation correlates with the severity of heart failure in patients developing cardiogenic shock.
-
- Orrem, Hilde L (author)
- Oslo University Hospital, Norway
-
- Nilsson, Per H., 1980- (author)
- Linnéuniversitetet,Institutionen för kemi och biomedicin (KOB),University of Oslo, Norway;Oslo University Hospital, Norway,Linnaeus Ctr Biomat Chem, BMC;HoRB
-
- Pischke, Søren E (author)
- Oslo University Hospital, Norway
-
show more...
-
- Grindheim, Guro (author)
- Oslo University Hospital, Norway
-
- Garred, Peter (author)
- University of Copenhagen, Denmark
-
- Seljeflot, Ingebjørg (author)
- Oslo University Hospital, Norway;University of Oslo, Norway
-
- Husebye, Trygve (author)
- Oslo University Hospital, Norway;University of Oslo, Norway
-
- Aukrust, Pål (author)
- University of Oslo, Norway;Oslo University Hospital, Norway
-
- Yndestad, Arne (author)
- University of Oslo, Norway;Oslo University Hospital, Norway
-
- Andersen, Geir Ø (author)
- Oslo University Hospital, Norway;University of Oslo, Norway
-
- Barratt-Due, Andreas (author)
- Oslo University Hospital, Norway
-
- Mollnes, Tom E (author)
- Oslo University Hospital, Norway;University of Oslo, Norway;University of Tromsø, Norway;Norwegian University of Science and Technology, Norway
-
show less...
-
(creator_code:org_t)
- 2018-02-09
- 2018
- English.
-
In: ESC Heart Failure. - : John Wiley & Sons. - 2055-5822. ; 5:3, s. 292-301
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://onlinelibrar...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- AIMS: Heart failure (HF) is an impending complication to myocardial infarction. We hypothesized that the degree of complement activation reflects severity of HF following acute myocardial infarction.METHODS AND RESULTS: The LEAF trial (LEvosimendan in Acute heart Failure following myocardial infarction) evaluating 61 patients developing HF within 48 h after percutaneous coronary intervention-treated ST-elevation myocardial infarction herein underwent a post hoc analysis. Blood samples were drawn from inclusion to Day 5 and at 42 day follow-up, and biomarkers were measured with enzyme immunoassays. Regional myocardial contractility was measured by echocardiography as wall motion score index (WMSI). The cardiogenic shock group (n = 9) was compared with the non-shock group (n = 52). Controls (n = 44) were age-matched and sex-matched healthy individuals. C4bc, C3bc, C3bBbP, and sC5b-9 were elevated in patients at inclusion compared with controls (P < 0.01). The shock group had higher levels compared with the non-shock group for all activation products except C3bBbP (P < 0.05). At Day 42, all products were higher in the shock group (P < 0.05). In the shock group, sC5b-9 correlated significantly with WMSI at baseline (r = 0.68; P = 0.045) and at Day 42 (r = 0.84; P = 0.036). Peak sC5b-9 level correlated strongly with WMSI at Day 42 (r = 0.98; P = 0.005). Circulating endothelial cell activation markers sICAM-1 and sVCAM-1 were higher in the shock group during the acute phase (P < 0.01), and their peak levels correlated with sC5b-9 peak level in the whole HF population (r = 0.32; P = 0.014 and r = 0.30; P = 0.022, respectively).CONCLUSIONS: Complement activation discriminated cardiogenic shock from non-shock in acute ST-elevation myocardial infarction complicated by HF and correlated with regional contractility and endothelial cell activation, suggesting a pathogenic role of complement in this condition.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Acute heart failure
- Cardiogenic shock
- Complement activation
- Inflammation
- Myocardial infarction
- Wall motion score index
- Medicin
- Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Orrem, Hilde L
-
Nilsson, Per H., ...
-
Pischke, Søren E
-
Grindheim, Guro
-
Garred, Peter
-
Seljeflot, Ingeb ...
-
show more...
-
Husebye, Trygve
-
Aukrust, Pål
-
Yndestad, Arne
-
Andersen, Geir Ø
-
Barratt-Due, And ...
-
Mollnes, Tom E
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cardiac and Card ...
- Articles in the publication
-
ESC Heart Failur ...
- By the university
-
Linnaeus University