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Synthesis of ZIF-8/...
Synthesis of ZIF-8/PVA microspheres with the assistance of a microfluidic device and their controlled drug release properties
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- Zeng, Changfeng (författare)
- College of Mechanical and Power Engineering, Nanjing Tech University, Nanjing, 211800, China
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- Li, Jie (författare)
- State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing 211800, China
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- Gong, Jie (författare)
- College of Chemical and Environmental Engineering, Jiangsu University of Technology, Changzhou 213001, Jiangsu, PR China
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- Zhang, Lixiong (författare)
- State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing 211800, China
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- Yu, Liang (författare)
- Luleå tekniska universitet,Kemiteknik
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(creator_code:org_t)
- Elsevier B.V. 2024
- 2024
- Engelska.
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Ingår i: Microporous and Mesoporous Materials. - : Elsevier B.V.. - 1387-1811 .- 1873-3093. ; 376
- Relaterad länk:
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https://doi.org/10.1...
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https://ltu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- ZIF-8/PVA microspheres with an even size were synthesized with the assistance of a simple microfluidic device. The ZIF-8/PVA microdroplets were first generated in a simple co-flow microfluidic device using a PVA aqueous solution dispersed with ZIF-8 nanoparticles as the dispersed phase and fatty acid methyl ester (FAME) as the continuous phase. Subsequently, the ZIF-8/PVA microdroplets were further extracted to form ZIF-8/PVA microspheres. The influence of the type of continuous phase on the sphericity of microspheres was investigated and the effect of ZIF-8 content was studied. Further studies showed that decreasing the extraction rate and using additives of NaCl in the dispersed phase could improve the sphericity of the ZIF-8/PVA microspheres. Finally, the synthesized ZIF-8/PVA microspheres were used to study the loading and release of tetracycline. The results showed that the loading of ZIF-8/PVA microspheres was more than 5 times higher than that of pure PVA microspheres. The drug release time of ZIF-8/PVA microspheres was much longer than that of the PVA microspheres and the release rate was significantly affected by the pH of the environment.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Elektroteknik och elektronik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Electrical Engineering, Electronic Engineering, Information Engineering (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering (hsv//eng)
Nyckelord
- Controlled drug release
- Microfluidics
- Solvent extraction
- Sphericity control
- ZIF-8/PVA microspheres
- Chemical Technology
- Kemisk teknologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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