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A comparison betwee...
A comparison between the structures of reconstituted salivary pellicles and oral mucin (MUC5B) films.
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- Boyd, Hannah, 1994- (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Malmö Univ, Dept Biomed Sci, S-20506 Malmö, Sweden.;Malmö Univ, Biofilms Res Ctr Biointerfaces, S-20506 Malmö, Sweden.
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- Gonzalez-Martinez, Juan F (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Malmö Univ, Dept Biomed Sci, S-20506 Malmö, Sweden.;Malmö Univ, Biofilms Res Ctr Biointerfaces, S-20506 Malmö, Sweden.
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- Welbourn, Rebecca J L (författare)
- ISIS Facility, STFC, Rutherford Appleton Laboratory, Chilton, Didcot, Oxon OX11 0QX, UK,Rutherford Appleton Lab, STFC, ISIS Facil, Didcot OX11 0QX, Oxon, England.
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- Gutfreund, Philipp (författare)
- Institut Laue Langevin, 71 avenue des Martyrs, Grenoble 38000, France,Inst Laue Langevin, 71 Ave Martyrs, F-38000 Grenoble, France.
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- Klechikov, Alexey (författare)
- Uppsala universitet,Materialfysik,Inst Laue Langevin, 71 Ave Martyrs, F-38000 Grenoble, France.
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- Robertsson, Carolina, 1993- (författare)
- Malmö universitet,Odontologiska fakulteten (OD),Biofilms Research Center for Biointerfaces,Malmö Univ, Biofilms Res Ctr Biointerfaces, S-20506 Malmö, Sweden.;Malmö Univ, Dept Oral Biol & Pathol, S-20506 Malmö, Sweden.
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- Wickström, Claes, 1970- (författare)
- Malmö universitet,Odontologiska fakulteten (OD),Biofilms Research Center for Biointerfaces,Malmö Univ, Biofilms Res Ctr Biointerfaces, S-20506 Malmö, Sweden.;Malmö Univ, Dept Oral Biol & Pathol, S-20506 Malmö, Sweden.
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- Arnebrant, Thomas (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Malmö Univ, Dept Biomed Sci, S-20506 Malmö, Sweden.;Malmö Univ, Biofilms Res Ctr Biointerfaces, S-20506 Malmö, Sweden.
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- Barker, Robert (författare)
- School of Physical Sciences, University of Kent, Canterbury, Kent CT2 7NH, UK,Univ Kent, Sch Phys Sci, Canterbury CT2 7NH, Kent, England.
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- Sotres, Javier (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Malmö Univ, Dept Biomed Sci, S-20506 Malmö, Sweden.;Malmö Univ, Biofilms Res Ctr Biointerfaces, S-20506 Malmö, Sweden.
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Journal of Colloid and Interface Science. - : Elsevier. - 0021-9797 .- 1095-7103. ; 584, s. 660-668
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- HYPOTHESIS: Salivary pellicles i.e., thin films formed upon selective adsorption of saliva, protect oral surfaces against chemical and mechanical insults. Pellicles are also excellent aqueous lubricants. It is generally accepted that reconstituted pellicles have a two-layer structure, where the outer layer is mainly composed of MUC5B mucins. We hypothesized that by comparing the effect of ionic strength on reconstituted pellicles and MUC5B films we could gain further insight into the pellicle structure.EXPERIMENTS: Salivary pellicles and MUC5B films reconstituted on solid surfaces were investigated at different ionic strengths by Force Spectroscopy, Quartz Crystal Microbalance with Dissipation, Null Ellipsometry and Neutron Reflectometry.FINDINGS: Our results support the two-layer structure for reconstituted salivary pellicles. The outer layer swelled when ionic strength decreased, indicating a weak polyelectrolyte behavior. While initially the MUC5B films exhibited a similar tendency, this was followed by a drastic collapse indicating an interaction between exposed hydrophobic domains. This suggests that mucins in the pellicle outer layer form complexes with other salivary components that prevent this interaction. Lowering ionic strength below physiological values also led to a partial removal of the pellicle inner layer. Overall, our results highlight the importance that the interactions of mucins with other pellicle components play on their structure.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Nyckelord
- Ionic strength
- MUC5B
- Mucin
- Salivary pellicle
- Steric forces
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Boyd, Hannah, 19 ...
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Gonzalez-Martine ...
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Welbourn, Rebecc ...
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Gutfreund, Phili ...
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Klechikov, Alexe ...
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Robertsson, Caro ...
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Wickström, Claes ...
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Arnebrant, Thoma ...
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Barker, Robert
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Sotres, Javier
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Odontologi
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- NATURVETENSKAP
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NATURVETENSKAP
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och Kemi
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och Fysikalisk kemi
- Artiklar i publikationen
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Journal of Collo ...
- Av lärosätet
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Malmö universitet
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Uppsala universitet