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Swelling kinetics o...
Swelling kinetics of mixtures of soybean phosphatidylcholine and glycerol dioleate
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- Engstedt, Jenni (författare)
- Malmö University,Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Camurus AB, Ideon Science Park, Lund SE-223 70, Sweden
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- in 't Zandt, René (författare)
- Lund University,Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,MR Physics,Forskargrupper vid Lunds universitet,Faculty of Medicine,Lund University Research Groups
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- Barauskas, Justas (författare)
- Camurus AB, Ideon Science Park, Lund SE-223 70, Sweden
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- Kocherbitov, Vitaly (författare)
- Malmö University,Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
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(creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: Colloids and Surfaces B. - : Elsevier. - 0927-7765 .- 1873-4367. ; 239
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Lipid-based drug delivery systems offer the potential to enhance bioavailability, reduce dosing frequency, and improve patient adherence. In aqueous environment, initially dry lipid depots take up water and form liquid crystalline phases. Variation of lipid composition, depot size and hydration-induced phase transitions will plausibly affect the diffusion in and out of the depot. Lipid depots of soybean phosphatidylcholine (SPC) and glycerol dioleate (GDO) mixtures were hydrated for varying time durations in a phosphate-buffered saline (PBS) buffer and then analyzed with Karl Fischer titration, magnetic resonance imaging (MRI) and gravimetrically. Mathematical modeling of the swelling process using diffusion equations, was used to estimate the parameters of diffusion. Both composition of lipid mixture and depot size affect swelling kinetics… The diffusion parameters obtained in Karl Fischer titration and MRI (with temporal and spatial resolution respectively) are in good agreement. Remarkably, the MRI results show a gradient of water content within the depot even after the end of diffusion process. Apparently contradicting the first Fick's law in its classical form, these results find an explanation using the generalized Fick's law that considers the gradient of chemical potential rather than concentration as the driving force of diffusion.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Kemi -- Fysikalisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Physical Chemistry (hsv//eng)
Nyckelord
- Generalized Fick’s law
- Hydration
- Lipid liquid crystalline depot
- Magnetic resonance imaging
- Phase equilibria
- Swelling kinetics
- Generalized Fick's law
- Hydration
- Lipid liquid crystalline depot
- Magnetic resonance imaging
- Phase equilibria
- Swelling kinetics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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