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Sarcolipin expressi...
Sarcolipin expression in human skeletal muscle : Influence of energy balance and exercise
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- Morales-Alamo, David (författare)
- Univ Las Palmas Gran Canaria, Las Palmas Gran Canaria, Spain; IUIBS, Las Palmas Gran Canaria, Canary Islands, Spain
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- Martinez-Canton, Miriam (författare)
- IUIBS, Las Palmas Gran Canaria, Canary Islands, Spain
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- Gelabert-Rebato, Miriam (författare)
- Univ Las Palmas Gran Canaria, Las Palmas Gran Canaria, Spain; IUIBS, Las Palmas Gran Canaria, Canary Islands, Spain; Nektium Pharma, Las Palmas Gran Canaria, Spain
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- Martin-Rincon, Marcos (författare)
- Univ Las Palmas Gran Canaria, Las Palmas Gran Canaria, Spain; IUIBS, Las Palmas Gran Canaria, Canary Islands, Spain
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- de Pablos-Velasco, Pedro (författare)
- IUIBS, Las Palmas Gran Canaria, Canary Islands, Spain; Hosp Univ Gran Canaria Doctor Negrin, Las Palmas Gran Canaria, Spain
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- Holmberg, Hans-Christer, 1958- (författare)
- Mittuniversitetet,Institutionen för hälsovetenskap,Swedish Winter Sports Res Ctr,Mittuniversitetet, Institutionen för hälsovetenskap
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- Calbet, Jose A. L. (författare)
- Univ Las Palmas Gran Canaria, Las Palmas Gran Canaria, Spain; IUIBS, Las Palmas Gran Canaria, Canary Islands, Spain; Norwegian Sch Sport Sci, Oslo, Norway
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(creator_code:org_t)
- 2019-12-05
- 2020
- Engelska.
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Ingår i: Scandinavian Journal of Medicine and Science in Sports. - : Wiley. - 0905-7188 .- 1600-0838. ; 30:3, s. 408-420
- Relaterad länk:
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https://accedacris.u...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Sarcolipin (SLN) is a SERCA uncoupling protein associated with exercise performance and lower adiposity in mice. To determine SLN protein expression in human skeletal muscle and its relationship with adiposity, resting energy expenditure (REE), and performance, SLN was assessed by Western blot in 199 biopsies from two previous studies. In one study, 15 overweight volunteers underwent a pretest followed by 4 days of caloric restriction and exercise (45-minute one-arm cranking + 8-hour walking), and 3 days on a control diet. Muscle biopsies were obtained from the trained and non-exercised deltoid, and vastus lateralis (VL). In another study, 16 men performed seven sessions of 4-6 x 30-sec all-out sprints on the cycle ergometer with both limbs, and their VL and triceps brachii biopsied pre- and post-training. SLN expression was twofold and 44% higher in the VL than in the deltoids and triceps brachii, respectively. SLN was associated with neither adiposity nor REE, and was not altered by a severe energy deficit (5500 kcal/day). SLN and cortisol changes after the energy deficit were correlated (r = .38, P = .039). SLN was not altered by low-intensity exercise in the overweight subjects, whereas it was reduced after sprint training in the other group. The changes in SLN with sprint training were inversely associated with the changes in gross efficiency (r = -.59, P = .016). No association was observed between aerobic or anaerobic performance and SLN expression. In conclusion, sarcolipin appears to play no role in regulating the fat mass of men. Sprint training reduces sarcolipin expression, which may improve muscle efficiency.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Nyckelord
- exercise
- obesity
- resting energy expenditure
- sarcolipin
- sprint training
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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