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Heterogeneity of ph...
Heterogeneity of phosphatidylcholine metabolism in nonalcoholic fatty liver disease
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- Qadri, Sami (författare)
- University of Helsinki and Helsinki University Hospital, Department of Medicine, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland
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- Blom, Sami (författare)
- Aiforia Technologies Oy, Helsinki, Finland
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- Pitkänen, Kari (författare)
- Aiforia Technologies Oy, Helsinki, Finland
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- Ahlholm, Noora (författare)
- University of Helsinki and Helsinki University Hospital, Department of Medicine, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland
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- Porthan, Kimmo (författare)
- University of Helsinki and Helsinki University Hospital, Department of Medicine, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland
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- Luukkonen, Panu K. (författare)
- University of Helsinki and Helsinki University Hospital, Department of Medicine, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland; Yale University, Department of Internal Medicine, New Haven, United States
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- Juuti, Anne (författare)
- University of Helsinki and Helsinki University Hospital, Department of Gastrointestinal Surgery, Abdominal Center, Helsinki, Finland
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- Sammalkorpi, Henna (författare)
- University of Helsinki and Helsinki University Hospital, Department of Gastrointestinal Surgery, Abdominal Center, Helsinki, Finland
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- Penttilä, Anne (författare)
- University of Helsinki and Helsinki University Hospital, Department of Gastrointestinal Surgery, Abdominal Center, Helsinki, Finland
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- Arola, Johanna (författare)
- University of Helsinki and Helsinki University Hospital, Department of Pathology, Helsinki, Finland
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- Oresic, Matej, 1967- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,University of Turku and Åbo Akademi University, Turku Bioscience Centre, Turku, Finland
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- Hyötyläinen, Tuulia, 1971- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Yki-Järvinen, Hannele (författare)
- University of Helsinki and Helsinki University Hospital, Department of Medicine, Helsinki, Finland; Minerva Foundation Institute for Medical Research, Helsinki, Finland
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Journal of Hepatology. - : Elsevier. - 0168-8278 .- 1600-0641. ; 77:Suppl. 1, s. S111-S111
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background and aims: In murine models of non-alcoholic fatty liver disease (NAFLD), liver damage associates with a deficiency of phosphatidylcholines (PCs), particularly polyunsaturated PCs (PUFA-PCs). We studied whether human PC metabolism is altered by NAFLD or by the protective genetic variant in HSD17B13 (rs72613567 T > TA).Method: In 143 obese patients with a liver biopsy and genotyping for HSD17B13 rs72613567, we analysed the hepatic lipidome (UPLC-MS). As the hepatic parenchymal fat fraction (HPFF) affects apparent concentrations of amphiphilic lipids, we normalised hepatic phospholipid concentrations to fat-free liver mass. To this end, we employed a state-of-the-art deep learning image analysis method (Aiforia Technologies) to accurately quantify HPFF in liver biopsies.Results: Total unadjusted hepatic PCs correlated negatively with HPFF (rs = −0.26, P < 0.01), but this association disappeared after normalising to fat-free liver mass (rs = 0.02, P = 0.81). With increasing HPFF, concentrations of especially saturated and monounsaturated PCs significantly increased, whereas concentrations of PUFA-PCs decreased. Accordingly, the hepatic triacylglycerol composition significantly correlated with that of hepatic PCs. In carriers of the protective variant in HSD17B13, as compared to non-carriers, the hepatic lipidome was enriched in especially PUFA-PCs.Conclusion: Patients with NAFLD have a deficiency of PUFA-PCs. The protective HSD17B13 rs72613567 variant opposes these changes, increasing intrahepatic PC concentrations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
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- vet (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Qadri, Sami
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Blom, Sami
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Pitkänen, Kari
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Ahlholm, Noora
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Porthan, Kimmo
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Luukkonen, Panu ...
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Juuti, Anne
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Sammalkorpi, Hen ...
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Penttilä, Anne
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Arola, Johanna
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Oresic, Matej, 1 ...
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Hyötyläinen, Tuu ...
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Yki-Järvinen, Ha ...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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Journal of Hepat ...
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Örebro universitet