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Urinary para-nitrop...
Urinary para-nitrophenol levels of pregnant women and cognitive and motor function of their children aged 2 years : Evidence from the SMBCS (China)
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- Zhang, Jiming (författare)
- School of Public Health/MOE Key Laboratory of Public Health Safety/NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
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- Li, Zeyu (författare)
- School of Public Health/MOE Key Laboratory of Public Health Safety/NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
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- Dai, Yiming (författare)
- School of Public Health/MOE Key Laboratory of Public Health Safety/NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
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- Guo, Jianqiu (författare)
- School of Public Health/MOE Key Laboratory of Public Health Safety/NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
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- Qi, Xiaojuan (författare)
- School of Public Health/MOE Key Laboratory of Public Health Safety/NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China; Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
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- Liu, Ping (författare)
- School of Public Health/MOE Key Laboratory of Public Health Safety/NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
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- Lv, Shenliang (författare)
- School of Public Health/MOE Key Laboratory of Public Health Safety/NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
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- Lu, Dasheng (författare)
- Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
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- Liang, Weijiu (författare)
- Shanghai Changning Center for Disease Control and Prevention, Shanghai, China
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- Chang, Xiuli (författare)
- School of Public Health/MOE Key Laboratory of Public Health Safety/NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
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- Cao, Yang, Associate Professor, 1972- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Clinical Epidemiology and Biostatistics
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- Wu, Chunhua (författare)
- School of Public Health/MOE Key Laboratory of Public Health Safety/NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
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- Zhou, Zhijun (författare)
- School of Public Health/MOE Key Laboratory of Public Health Safety/NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai, China
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(creator_code:org_t)
- Academia Press, 2022
- 2022
- Engelska.
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Ingår i: Ecotoxicology and Environmental Safety. - : Academia Press. - 0147-6513 .- 1090-2414. ; 244
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Urinary para-nitrophenol (PNP), an exposure biomarker of ethyl parathion (EP) and methyl parathion (MP) pesticides, was still pervasively detected in the general population even after global restriction for years. And the concern whether there is an association of PNP level with child development of the nervous system is increasing. The current study aimed to evaluate the maternal urinary PNP concentrations during late pregnancy and the associations of PNP levels with cognitive and motor function of their children at the age of 2 years.METHODS: 323 mother-child pairs from the Sheyang Mini Birth Cohort Study were included in the current study. Gas chromatography-tandem mass spectrometry was used to measure concentrations of PNP, the specific metabolite of EP and MP, in maternal urine samples during pregnancy. Developmental quotients (DQs) scores measured with Gesell Developmental Scales were employed to evaluate cognitive and motor function of children aged 2 years. Generalized linear models were performed to analyze the associations of PNP concentrations in pregnant women's urine samples with cognitive and motor function of their children.RESULTS: Maternal PNP was detected in all urine samples with a median of 4.11 μg/L and a range from 0.57 μg/L to 109.13 μg/L, respectively. Maternal urinary PNP concentrations showed a negative trend with DQ of motor area [regression coefficient (β) = - 1.35; 95 % confidence interval (95 %CI): - 2.37, - 0.33; P < 0.01], and the children whose mothers were in the fourth quartile exposure group performed significantly worse compared to the reference group (β = - 1.11; 95 %CI: - 1.80, - 0.42; P < 0.01). As for average DQ score, children with their mothers' urinary PNP concentrations in the third quartile group had higher scores than those in the first quartile group (β = 0.39; 95 %CI: 0.03, 0.75; P = 0.04). In sex-stratified analyses, a negative trend between maternal urinary PNP concentrations and DQ scores in motor area of children was only observed in boys (β = - 1.62; 95 %CI: - 2.80, - 0.43; P < 0.01). Boys in the third quartile group had higher DQ average scores than those in the lowest quartile as reference (β = 0.53; 95 %CI: 0.02, 1.04; P = 0.04).CONCLUSIONS: The mothers from SMBCS may be widely exposed to EP and/or MP, which were associated with the cognitive and motor function of their children aged 2 years in a sex-specific manner. Our results might provide epidemiology evidence on the potential effects of prenatal exposure to EP and/or MP on children's cognitive and motor function.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Child cognitive and motor function
- Ethyl parathion
- Methyl parathion
- Para-nitrophenol
- Pesticide exposure
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Zhang, Jiming
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Li, Zeyu
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Dai, Yiming
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Guo, Jianqiu
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Qi, Xiaojuan
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Liu, Ping
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Lv, Shenliang
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Lu, Dasheng
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Liang, Weijiu
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Chang, Xiuli
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Cao, Yang, Assoc ...
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Wu, Chunhua
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Zhou, Zhijun
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
- Artiklar i publikationen
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Ecotoxicology an ...
- Av lärosätet
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Örebro universitet
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Karolinska Institutet