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Intravenous anti-P....
Intravenous anti-P. aeruginosa IgY-antibodies do not decrease pulmonary bacterial concentrations in a porcine model of ventilator-associated pneumonia
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- Otterbeck, Alexander (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Skorup, Paul (författare)
- Uppsala universitet,Infektionsmedicin
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- Hanslin, Katja (författare)
- Uppsala universitet,Anestesiologi och intensivvård
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- Larsson, Anders (författare)
- Uppsala universitet,Klinisk kemi
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- Stålberg, J (författare)
- Uppsala universitet,Klinisk kemi
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- Hjelmqvist, Hans, 1958- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Anesthesiology and Intensive Care, School of Medical Sciences, 98837Örebro University, Örebro, Sweden.
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- Lipcsey, Miklós (författare)
- Uppsala universitet,Hedenstiernalaboratoriet
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(creator_code:org_t)
- 2022-11-13
- 2022
- Engelska.
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Ingår i: Innate Immunity. - : Sage Publications. - 1753-4259 .- 1753-4267. ; 28:7-8, s. 224-234
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Ventilator associated pneumonia (VAP) caused by P. aeruginosa is a cause of morbidity and mortality in critically ill patients. The spread of pathogens with anti-microbial resistance mandates the investigation of novel therapies. Specific polyclonal anti-P. aeruginosa IgY-antibodies (Pa-IgY) might be effective for VAP caused by P. aeruginosa. The objective of this study was to investigate if intravenous Pa-IgY decreases the lower airway concentration of P. aeruginosa in VAP. We used a double blind randomized placebo controlled porcine model of VAP caused by P. aeruginosa. Eighteen pigs were randomized to either receive intravenous Pa-IgY or placebo. Repeated registration of physiological parameters and sampling was performed for 27 h. Concentration of P. aeruginosa in BAL-cultures was similar in both groups with 104.97 ± 102.09 CFU/mL in the intervention group vs 104.37 ± 102.62 CFU/mL in the control group at the end of the experiment. The intervention group had higher heart rate, cardiac index, oxygen delivery and arterial oxygen tension/fraction of inspired oxygen-ratio, but lower plasma lactate and blood hemoglobin levels than the control group. In summary, in an anesthetized and mechanically ventilated porcine model of VAP, Pa-IgY at the dose used did not decrease concentrations of P. aeruginosa in the lower airways.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- Anti-microbial resistance
- chicken antibodies
- hospital acquired pneumonia (HAP)
- pneumonia
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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