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Fecal microbiota tr...
Fecal microbiota transplantation for the treatment of irritable bowel syndrome : A systematic review and meta-analysis
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- Halkjær, Sofie Ingdam (författare)
- Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
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- Lo, Bobby (författare)
- Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
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- Cold, Frederik (författare)
- Copenhagen University Hospital Hvidovre, Hvidovre, Denmark
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Højer Christensen, Alice (författare)
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- Holster, Savanne (författare)
- Faculty of Medicine and Health, School of Medical Sciences, Örebro University, Örebro, Sweden,Nutrition-Gut-Brain Interactions Research Centre
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- König, Julia, 1983- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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- Brummer, Robert Jan, 1957- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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- Aroniadis, Olga C. (författare)
- Renaissance School of Medicine, Stony Brook University Hospital, New York, NY 11794-8434, United States
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- Lahtinen, Perttu (författare)
- Central Hospital, Lahti 15850, Finland; University of Helsinki, Helsinki 00014, Finland
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- Holvoet, Tom (författare)
- University Hospital Ghent, Ghent 9000, Belgium
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- Gluud, Lise Lotte (författare)
- University of Copenhagen, Copenhagen 2200, Denmark
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- Petersen, Andreas Munk (författare)
- Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; University of Copenhagen, Copenhagen 2200, Denmark
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(creator_code:org_t)
- Baishideng Publishing Group Inc. 2023
- 2023
- Engelska.
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Ingår i: World Journal of Gastroenterology. - : Baishideng Publishing Group Inc.. - 1007-9327 .- 2219-2840. ; 29:20, s. 3185-3202
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https://doi.org/10.3...
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https://oru.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
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- BACKGROUND; Irritable bowel syndrome (IBS) is the most prevalent gastrointestinal disorder in developed countries and reduces patients’ quality of life, hinders their ability to work, and increases health care costs. A growing number of trials have demonstrated an aberrant gut microbiota composition in IBS, also known as ‘gut dysbiosis’. Fecal microbiota transplantation (FMT) has been suggested as a treatment for IBS.AIM: To assess the efficacy and safety of FMT for the treatment of IBS.METHODS: We searched Cochrane Central, MEDLINE, EMBASE and Web of Science up to 24 October 2022 for randomised controlled trials (RCTs) investigating the effectiveness of FMT compared to placebo (including autologous FMT) in treating IBS. The primary outcome was the number of patients with improvements of symptoms measured using a validated, global IBS symptoms score. Secondary outcomes were changes in quality-of-life scores, non-serious and serious adverse events. Risk ratios (RR) and corresponding 95%CI were calculated for dichotomous outcomes, as were the mean differences (MD) and 95%CI for continuous outcomes. The Cochrane risk of bias tool was used to assess the quality of the trials. GRADE criteria were used to assess the overall quality of the evidence.RESULTS: Eight RCTs (484 participants) were included in the review. FMT resulted in no significant benefit in IBS symptoms three months after treatment compared to placebo (RR 1.19, 95%CI: 0.68-2.10). Adverse events were reported in 97 participants in the FMT group and in 45 participants in the placebo group (RR 1.17, 95%CI: 0.63-2.15). One serious adverse event occurred in the FMT group and two in the placebo group (RR 0.42, 95%CI: 0.07-2.60). Endoscopic FMT delivery resulted in a significant improvement in symptoms, while capsules did not. FMT did not improve the quality of life of IBS patients but, instead, appeared to reduce it, albeit non significantly (MD -6.30, 95%CI: -13.39-0.79). The overall quality of the evidence was low due to moderate-high inconsistency, the small number of patients in the studies, and imprecision.CONCLUSION: We found insufficient evidence to support or refute the use of FMT for IBS. Larger trials are needed
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Fecal microbiota transplantation
- Irritable bowel syndrome
- Meta-analysis
- Systematic review
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Halkjær, Sofie I ...
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Lo, Bobby
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Cold, Frederik
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Højer Christense ...
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Holster, Savanne
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König, Julia, 19 ...
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Brummer, Robert ...
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Aroniadis, Olga ...
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Lahtinen, Perttu
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Holvoet, Tom
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Gluud, Lise Lott ...
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Petersen, Andrea ...
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Örebro universitet