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Genomic analysis of...
Genomic analysis of Staphylococcus aureus along a pork production chain and in the community, Shandong Province, China
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- Sun, Chengtao (författare)
- Beijing Advanced Innovation Centre for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China
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- Chen, Baoli (författare)
- Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Centre for Disease Control and Prevention, Jinan, Shandong, China,Shandong Ctr Dis Control and Prevent, Peoples R China
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- Hulth, Anette (författare)
- Karolinska Institutet,Publ Hlth Agcy Sweden, Sweden; Karolinska Inst, Sweden
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- Schwarz, Stefan (författare)
- Beijing Advanced Innovation Centre for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China; Institute of Microbiology and Epizootics, Centre for Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany,China Agr Univ, Peoples R China; Free Univ Berlin, Germany
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- Ji, Xing (författare)
- Beijing Advanced Innovation Centre for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China
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- Nilsson, Lennart E (författare)
- Linköpings universitet,Avdelningen för mikrobiologi, infektion och inflammation,Medicinska fakulteten
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- Ma, Shizhen (författare)
- Beijing Advanced Innovation Centre for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China
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- Sun, Qiang (författare)
- Shandong University, Centre for Health Management and Policy, Jinan, Shandong, China; NHFPC (Shandong University), Key Laboratory of Health Economics and Policy Research, Jinan, Shandong, China,Shandong Univ, Peoples R China
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- Bi, Zhenwang (författare)
- Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Centre for Disease Control and Prevention, Jinan, Shandong, China,Shandong Ctr Dis Control and Prevent, Peoples R China
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- Wang, Yang (författare)
- Beijing Advanced Innovation Centre for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China
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- Bi, Zhenqiang (författare)
- Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Centre for Disease Control and Prevention, Jinan, Shandong, China
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- Wu, Congming (författare)
- Beijing Advanced Innovation Centre for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, China,China Agr Univ, Peoples R China
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- Börjesson, Stefan, 1979- (författare)
- Linköpings universitet,Avdelningen för mikrobiologi, infektion och inflammation,Medicinska fakulteten,Natl Vet Inst SVA, Sweden
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(creator_code:org_t)
- Elsevier, 2019
- 2019
- Engelska.
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Ingår i: International Journal of Antimicrobial Agents. - : Elsevier. - 0924-8579 .- 1872-7913. ; 54:1, s. 8-15
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Livestock-associated meticillin-resistant Staphylococcus aureus (LA-MRSA) is an increasingly important public health concern worldwide; however, data on LA-MRSA from Asian countries is scarce. As such, a comprehensive molecular epidemiological survey of S. aureus along a pork production chain and in the community was undertaken in Shandong Province, China. spa typing and whole-genome sequencing were used to survey the occurrence and potential transmission of S. aureus in various sectors, including 899 porcine samples (snout or skin swabs, carcass swabs and pork portions), 845 human nasal samples and 239 environmental samples from commercial farms, a slaughterhouse, a pork wholesale market and the surrounding community. MRSA was detected in higher frequencies in samples from two commercial pig farms (pigs, 49%; farm workers, 64%; environmental samples, 16%) than in samples from the slaughterhouse (fatteners, 8.2%; carcasses, 1.1%; operation workers, 0%; environmental samples, 3.8%), the pork wholesale market (pork, 14%; sellers, 0%) and individuals in the community (6.8%). There were significant differences in population structures, antimicrobial susceptibility profiles, and the presence of resistance and virulence genes between human- and pig-associated isolates. The phylogenetic analysis confirmed the dissemination of LA-MRSA between various segments along the pork production chain. However, MRSA of the same sequence type was not found to be disseminated between the commercial farms and the surrounding communities. Furthermore, one MRSA ST398 was observed, and a novel CC9 variant ST3597 was detected within the chain. The high MRSA carriage rates and the emergence of a new MRSA CC9 variant identified in this study highlight the need for MRSA surveillance.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- China
- Community
- LA-MRSA
- Pork production chain
- Whole-genome sequencing
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Sun, Chengtao
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Chen, Baoli
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Hulth, Anette
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Schwarz, Stefan
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Ji, Xing
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Nilsson, Lennart ...
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visa fler...
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Ma, Shizhen
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Sun, Qiang
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Bi, Zhenwang
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Wang, Yang
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Bi, Zhenqiang
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Wu, Congming
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Börjesson, Stefa ...
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visa färre...
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NATURVETENSKAP
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Örebro universitet
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Karolinska Institutet
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Linköpings universitet