onr:"swepub:oai:DiVA.org:oru-108232"
Search: onr:"swepub:oai:DiVA.org:oru-108232" > The role of caspase...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Lindblad, Anna,1987-Örebro universitet,Institutionen för medicinska vetenskaper (author)
The role of caspase-1, caspase-4, NLRP3 and IL-1RA in bladder epithelial cells infected by uropathogenic Escherichia coli
- BookEnglish2023
Publisher, publication year, extent ...
- Örebro :Örebro University,2023
- 72 s.
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:oru-108232
- ISBN:9789175295268
- ISBN:9789175295275
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-108232URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Series
- Örebro Studies in Medicine,1652-4063 ;284
Notes
- Urinary tract infection is one of the most common infections and is mostlycaused by uropathogenic Escherichia coli (UPEC). The inflammasomeassociatedproteins caspase-1, caspase-4 and NLRP3 are essential in the hostcell response during urinary tract infection by regulating IL-1β release. Thepro-inflammatory effects of IL-1β can be inhibited by binding of the IL-1receptor antagonist (IL-1RA) to the IL-1 receptor. The aim of this thesis is toinvestigate what role caspase-1, caspase-4, NLRP3 and IL-1RA have on the proinflammatoryhost response evoked by UPEC and their role in recurrent UTI.The results showed that the inflammasome-associated proteinscaspase-1, caspase-4 and NLRP3 are involved in cytokine and chemokinerelease and in antimicrobial activities of neutrophils during UTI. Weconclude that IL-1RA influences the release of various inflammatoryproteins during a UPEC infection from bladder epithelial cells. In addition,deficiency in IL-1RA led to decreased UPEC colonization and invasion ofbladder epithelial cells. Our results also show that NLRP3 has a regulativefunction on estrogen signalling and the expression of antimicrobialpeptides. Additionally, we found that capsase-1 and caspase-4 can regulatethe gene expression of important immune regulators, including TLR4,antimicrobial peptides, cytokines and chemokines.Together, our results show that that the inflammasome-associatedproteins caspase-1, caspase-4, NLRP3 and IL-IRA are important immuneregulatorsduring UPEC infection in bladder epithelial cells. They regulateUPEC colonization, cytokines and chemokines release, antimicrobialactivities of neutrophils and estrogen signalling.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Andra medicinska och farmaceutiska grundvetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Other Basic Medicine hsv//eng
- Urinary tract infection
- inflammasome
- uropathogenic Escherichia coli
- NLRP3
- caspase-1
- caspase-4
- IL-1RA
- antimicrobial peptides
- estrogen
Added entries (persons, corporate bodies, meetings, titles ...)
- Demirel, Isak,1987-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)idl (thesis advisor)
- Yadav, Manisha,professorDr. B.R. Ambedkar Center for Biomedical Research (ACBR) University of Delhi, Delhi, India (opponent)
- Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)
Internet link
- https://oru.diva-portal.org/smash/get/diva2:1796362/PREVIEW01.pngpreview image
- https://oru.diva-portal.org/smash/get/diva2:1796362/COVER01.pdfcover
- https://oru.diva-portal.org/smash/get/diva2:1796362/FULLTEXT01.pdffulltext
- https://oru.diva-portal.org/smash/get/diva2:1796362/SPIKBLAD01.pdfspikblad
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-108232
Find in a library
- The role of caspase-1, caspase-4, NLRP3 and IL-1RA in bladder epithelial cells i... (Search the publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Lindblad, Anna, ...
- Demirel, Isak, 1 ...
- Yadav, Manisha, ...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Other Basic Medi ...
- Parts in the series
- Örebro Studies i ...
- By the university
- Örebro University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
