Search: onr:"swepub:oai:DiVA.org:oru-111028" >
Long-Term Effect of...
Long-Term Effect of Maintenance Electroconvulsive Therapy in Patients With Depression-Data From a Small Randomized Controlled Trial
-
- Brus, Ole, 1982- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Clinical epidemiology and biostatistics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
-
- Cao, Yang, Associate Professor, 1972- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Clinical epidemiology and biostatistics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
-
- Carlborg, Andreas (author)
- Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
-
show more...
-
- Engström, Ingemar, 1952- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
-
- von Knorring, Lars (author)
- Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden
-
- Nordenskjöld, Axel, 1977- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
-
show less...
-
(creator_code:org_t)
- 2024
- 2024
- English.
-
In: Journal of ECT. - : Lippincott Williams & Wilkins. - 1095-0680 .- 1533-4112.
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- OBJECTIVES: This study aimed to compare the long-term effects of maintenance electroconvulsive therapy (M-ECT) with medication and medication only in patients with depression.METHODS: A randomized controlled trial of 1 year of M-ECT with medication or medication only investigated relapse/recurrence among 56 patients in remission after electroconvulsive therapy (ECT) for depression was conducted. The results of the first year are published already and showed a significant advantage of M-ECT with medication.The current study was a long-term follow-up. When the randomized treatment allocation ended, medication was continued in both groups but M-ECT was terminated. Patients were followed for up to 10 years via Swedish national registers until the study endpoint of a new psychiatric diagnosis as an inpatient, suicide, suspected suicide, or death of another cause. Time to relapse was compared between the M-ECT with medication group and the medication-only group using Kaplan-Meier estimates.RESULTS: The median follow-up time was 6.5 years for the M-ECT and medication group and 3.1 years for the medication-only group. One year after randomization 22 patients remained in the M-ECT and medication group, and 14 patients remained in the medication-only group. Relapse patterns between the treatment groups after the completion of M-ECT seemed to be similar according to visual inspection.CONCLUSIONS: This long-term follow-up study suggests that most of the benefit achieved during the treatment period with M-ECT is maintained over several years, but the small sample size, with accompanying large statistical imprecision, makes the results uncertain. More long-term studies of M-ECT are required.Trial registration: ClinicalTrials.gov identifier: NCT00627887.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database