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Extracellular vesic...
Extracellular vesicles : pathogenetic, diagnostic and therapeutic value in traumatic brain injury
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- Mondello, Stefania (author)
- Oasi Research Institute-IRCCS, Troina, Italy; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy
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- Thelin, Eric P. (author)
- Karolinska Institutet,Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Neurosciences, Division of Neurosurgery, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom
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- Shaw, Gerry (author)
- EnCor Biotechnology Inc ., Gainesville, Forida, USA
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- Salzet, Michel (author)
- Laboratoire Protéomique, Réponse Inflammatoire et Spectrométrie de Masse (PRISM), Université de Lille, Lille, France
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- Visalli, Carmella (author)
- Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy
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- Cizkova, Dasa (author)
- Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia
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- Kobeissy, Firas (author)
- Department of Psychiatry and Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Forida, USA; Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon
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- Büki, Andras, 1966- (author)
- Department of Neurosurgery, Pecs University, Pecs, Hungary
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(creator_code:org_t)
- 2018-04-25
- 2018
- English.
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In: Expert Review of Proteomics. - : Taylor & Francis. - 1478-9450 .- 1744-8387. ; 15:5, s. 451-461
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Accurate classification according to injury-specific and patient-specific characteristics is critical to help informed clinical decision-making and to the pursuit of precision medicine in TBI. Reliable biomarker signatures for improved TBI diagnostics are required but still an unmet need. Areas covered: Extracellular vesicles (EVs) represent a new class of biomarker candidates in TBI. These nano-sized vesicles have key roles in cell signaling profoundly impacting pathogenic pathways, progression and long-term sequelae of TBI. As such EVs might provide novel neurobiological insights, enhance our understanding of the molecular mechanisms underlying TBI pathophysiology and recovery, and serve as biomarker signatures and therapeutic targets and delivery systems. Expert commentary: EVs are fast gaining momentum in TBI research, paving the way for new transformative diagnostic and treatment approaches. Their potential to sort out TBI variability and active involvement in the mechanisms underpinning different clinical phenotypes point out unique opportunities for improved classification, risk-stratification ad intervention, harboring promise of predictive, personalized, and even preemptive therapeutic strategies. Although a great deal of progress has been made, substantial efforts are still required to ensure the needed rigorous validation and reproducibility for clinical implementation of EVs.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- TBI
- traumatic brain injury
- biomarker
- exosomes
- extracellular vesicles
- microvesicles
Publication and Content Type
- ref (subject category)
- for (subject category)
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