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A novel PARP inhibi...
A novel PARP inhibitor L-2286 in a rat model of impact acceleration head injury : an immunohistochemical and behavioral study
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- Kövesdi, Erzsébet (författare)
- Department of Neurosurgery, University of Pécs, Hungary
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- Bukovics, Péter (författare)
- Department of Neurosurgery, University of Pécs, Hungary
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- Besson, Valérie (författare)
- Laboratoire de Pharmacologie de la Circulation Cérébrale, UPRES EA 2510, Université René Descartes, Paris, France
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- Nyirádi, József (författare)
- Department of Neurosurgery, University of Pécs, Hungary
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- Lückl, János (författare)
- Department of Neurosurgery, University of Pécs, Hungary
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- Pál, József (författare)
- Department of Neurosurgery, University of Pécs, Hungary
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- Sümegi, Balázs (författare)
- Department of BioChemistry, University of Pécs, Pécs, Hungary
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- Dóczi, Tamás (författare)
- Department of Neurosurgery, University of Pécs, Hungary
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- Hernádi, István (författare)
- Department of Experimental Zoology and Neurobiology, University of Pécs, Hungary
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- Büki, Andras, 1966- (författare)
- Department of Neurosurgery, University of Pécs, Hungary
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(creator_code:org_t)
- 2010-03-26
- 2010
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 11:4, s. 1253-1268
- Relaterad länk:
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https://doi.org/10.3...
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- We examined the neuro/axono-protective potential of a novel poly (ADP-ribose) polymerase (PARP) inhibitor L-2286 in a rat impact acceleration brain injury model. Male Wistar rats (n = 70) weighing 300-350 grams were used to determine the most effective intracerebroventricular (i.c.v.) dose of L-2286 administered 30 min after injury, and to test the neuroprotective effect at two time points (immediately, and 30 min after injury). The neuroprotective effect of L-2286 was tested using immunohistochemical (amyloid precursor protein and mid-sized mouse anti-neurofilament clone RMO-14.9 antibody) and behavioral tests (beam-balance, open-field and elevated plus maze). At both time-points, a 100 microg/rat dose of i.c.v. L-2286 significantly (p < 0.05) reduced the density of damaged axons in the corticospinal tract and medial longitudinal fascicle compared to controls. In the behavioral tests, treatment 30 min post-injury improved motor function, while the level of anxiety was reduced in both treatment protocols.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- PARP-inhibitor
- impact acceleration model
- traumatic brain injury
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Kövesdi, Erzsébe ...
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Bukovics, Péter
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Besson, Valérie
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Nyirádi, József
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Lückl, János
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Pál, József
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Sümegi, Balázs
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Dóczi, Tamás
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Hernádi, István
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Büki, Andras, 19 ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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Örebro universitet