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Genetic variants of...
Genetic variants of TNFSF4 and risk for carotid artery disease and stroke
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- Olofsson, P. S. (author)
- Karolinska Institutet
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- Söderström, L. Å. (author)
- Karolinska Institutet
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- Jern, Christina, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
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- Sirsjö, Allan (author)
- Örebro universitet,Hälsoakademin,Department of Clinical Medicine
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- Ria, M. (author)
- Karolinska Institutet
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- Sundler, E. (author)
- Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
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- De Faire, U. (author)
- Karolinska Institutet
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- Wiklund, Per-Gunnar (author)
- Umeå universitet,Medicin
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- Öhrvik, J. (author)
- Karolinska Institutet
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- Hedin, U. (author)
- Karolinska Institutet
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- Paulsson-Berne, G. (author)
- Karolinska Institutet
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- Hamsten, A. (author)
- Karolinska Institutet
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- Eriksson, P. (author)
- Karolinska Institutet
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- Hansson, G. K. (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2008-11-08
- 2009
- English.
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In: Journal of Molecular Medicine. - New York : Springer. - 0946-2716 .- 1432-1440. ; 87:4, s. 337-346
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https://doi.org/10.1...
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Abstract
Subject headings
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- In two independent human cohorts, the minor allele of SNP rs3850641 in TNFSF4 was significantly more frequent in individuals with myocardial infarction than in controls. In mice, Tnfsf4 expression is associated with increased atherosclerosis. The expression of TNFSF4 in human atherosclerosis and the association between genotype and cerebrovascular disease have not yet been investigated. TNFSF4 messenger RNA (mRNA) levels were significantly higher in human atherosclerotic lesions compared with controls (730â±â30 vs 330â±â65 arbitrary units, pâ<â0.01). TNFSF4 was mainly expressed by macrophages in atherosclerotic lesions. In cell culture, endothelial cells upregulated TNFSF4 in response to tumor necrosis factor alpha (TNF-α; 460â±â110 vs 133â±â8 arbitrary units, pâ<â0.001 after 6 h of stimulation). We analyzed the TNFSF4 gene in 239 patients who had undergone carotid endarterectomy and 138 matching controls from The Biobank of Karolinska Carotid Endarterectomies and Stockholm Heart Epidemiology Program cohorts and 929 patients and 1,382 matching controls from the Sahlgrenska Academy Study on Ischemic Stroke and Case Control Study of Stroke cohorts, limiting inclusion to patients with ischemic stroke. Participants were genotyped for the rs3850641 SNP in TNFSF4. Genotype associations were neither found with TNFSF4 mRNA levels nor with atherosclerosis associated systemic factors or risk for stroke. This study shows that TNFSF4 is expressed on antigen-presenting cells in human carotid atherosclerotic lesions but provides no evidence for an association of TNFSF4 gene variation with the risk for ischemic stroke.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
Keyword
- Atherosclerosis
- Cerebrovascular disease
- Gene expression
- Inflammation
- Single nucleotide polymorphism
- MEDICINE
- MEDICIN
- Medicine
- Medicin
- Atherosclerosis
- Cerebrovascular disease
- Inflammation
- Single nucleotide polymorphism
- Gene expression
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Olofsson, P. S.
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Söderström, L. Å ...
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Jern, Christina, ...
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Sirsjö, Allan
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Ria, M.
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Sundler, E.
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show more...
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De Faire, U.
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Wiklund, Per-Gun ...
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Öhrvik, J.
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Hedin, U.
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Paulsson-Berne, ...
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Hamsten, A.
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Eriksson, P.
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Hansson, G. K.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and General Practice
- Articles in the publication
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Journal of Molec ...
- By the university
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Örebro University
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University of Gothenburg
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Umeå University
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Karolinska Institutet