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HIV, Chlamydia trac...
HIV, Chlamydia trachomatis and Helicobacter pylori vaccine antigen and proteinaceous adjuvant production in arabidopsis and carrot
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- Strid, Åke, 1960- (author)
- Örebro universitet,Akademin för naturvetenskap och teknik,Biokemi
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- Lindh, Ingrid (author)
- Örebro universitet,Akademin för naturvetenskap och teknik,Biokemi
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- Kalbina, Irina, 1961- (author)
- Örebro universitet,Akademin för naturvetenskap och teknik,Biokemi
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- Engstrand, Lars (author)
- Smittskyddsinstitutet, The Public Health Agency, Solna, Sweden
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- Lycke, Nils (author)
- Gothenburg University, Gothenburg, Sweden
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- Marks, Ellen (author)
- Gothenburg University, Gothenburg, Sweden
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- Applequist, Steve (author)
- Karolinska Institute, Stockholm, Sweden
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- Andersson, Sören, 1957- (author)
- Örebro University Hospital, Örebro, Sweden
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(creator_code:org_t)
- Bryssel : COST, 2010
- 2010
- English.
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In: Molecular farming. - Bryssel : COST. ; , s. 17-17
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- In our project, we use plants for synthesis of vaccine antigens and adjuvant proteins. Among targeted diseases are HIV, Chlamydia trachomatis (CT) and Helicobacter pylori (HP) infections. Novel genetic constructs have been designed for production of optimized antigen proteins and several transformation techniques and intracellular protein production sites are being examined for yield optimization. Both Arabidopsis thaliana (HIV, CT, HP) and carrot (HIV, CT) have been successfully used as production hosts and plant-produced antigens against HIV (primarily the p24 protein), CT (own designed chimera of the MOMP protein) and HP (different versions of the TonB protein). For HIV and CT these antigens have been used in immunization trials in laboratory mice, giving rise to systemic immune responses. For this purpose both consumption of plant tissue and distribution of purified antigens have been used. For CT, the administration of the recombinant protein has also been shown to protect against the disease in mice. Moreover, to further increase the effect of vaccine antigens, we also use plants to produce protein-based adjuvants for inclusion in vaccine formulations. These adjuvants are based either on the bacterial flagellin protein or are cholera toxin-derived chimeric proteins.
Subject headings
- LANTBRUKSVETENSKAPER -- Bioteknologi med applikationer på växter och djur -- Växtbioteknologi (hsv//swe)
- AGRICULTURAL SCIENCES -- Agricultural Biotechnology -- Plant Biotechnology (hsv//eng)
Keyword
- Biochemistry
- Biokemi
Publication and Content Type
- ref (subject category)
- kon (subject category)
To the university's database
- By the author/editor
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Strid, Åke, 1960 ...
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Lindh, Ingrid
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Kalbina, Irina, ...
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Engstrand, Lars
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Lycke, Nils
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Marks, Ellen
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show more...
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Applequist, Stev ...
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Andersson, Sören ...
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show less...
- About the subject
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Agricultural Bio ...
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and Plant Biotechnol ...
- Articles in the publication
- Molecular farmin ...
- By the university
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Örebro University