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Training at high ex...
Training at high exercise intensity promotes qualitative adaptations of mitochondrial function in human skeletal muscle
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- Daussin, Frederic (författare)
- University of Strasbourg, Faculty of Medicine, Physiology Department, Strasbourg, FRANCE,UPRES E.A. 3072
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- Zoll, Joffrey (författare)
- University of Strasbourg, Faculty of Medicine, Physiology Department, Strasbourg, FRANCE,UPRES E.A. 3072
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- Ponsot, Elodie, 1973- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Muscle & Exercise Physiology Research Group, RISPA
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- Dufour, Stephane (författare)
- Faculty of Sport Sciences, University of Strasbourg, Strasbourg, FRANCE
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- Doutreleau, Stephane (författare)
- Physiology and Functional Explorations Department, New Civil Hospital, Strasbourg, FRANCE
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- Lonsdorfer, Evelyne (författare)
- Physiology and Functional Explorations Department, New Civil Hospital, Strasbourg, FRANCE
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- Ventura-Clapier, Renée (författare)
- Inserm UMR-S 769, LabEx LERMIT, Châtenay-Malabry, F-92296, France.
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Mettauer, Bertrand (författare)
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- Piquard, Francois (författare)
- University of Strasbourg, Faculty of Medicine, Physiology Department, Strasbourg, FRANCE,UPRES E.A. 3072
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- Geny, Bernard (författare)
- University of Strasbourg, Faculty of Medicine, Physiology Department, Strasbourg, FRANCE,UPRES E.A. 3072
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Richard, Ruddy (författare)
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University of Strasbourg, Faculty of Medicine, Physiology Department, Strasbourg, FRANCE UPRES EA. 3072 (creator_code:org_t)
- American Physiological Society, 2008
- 2008
- Engelska.
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Ingår i: Journal of applied physiology. - : American Physiological Society. - 8750-7587 .- 1522-1601. ; 104:5, s. 1436-1441
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- This study explored mitochondrial capacities to oxidize carbohydrate and fatty acids and functional optimization of mitochondrial respiratory chain complexes in athletes who regularly train at high exercise intensity (ATH, n = 7) compared with sedentary (SED, n = 7). Peak O(2) uptake (Vo(2max)) was measured, and muscle biopsies of vastus lateralis were collected. Maximal O(2) uptake of saponin-skinned myofibers was evaluated with several metabolic substrates [glutamate-malate (V(GM)), pyruvate (V(Pyr)), palmitoyl carnitine (V(PC))], and the activity of the mitochondrial respiratory complexes II and IV were assessed using succinate (V(s)) and N,N,N',N'-tetramethyl-p-phenylenediamine dihydrochloride (V(TMPD)), respectively. Vo(2max) was higher in ATH than in SED (57.8 +/- 2.2 vs. 31.4 +/- 1.3 ml.min(-1).kg(-1), P < 0.001). V(GM) was higher in ATH than in SED (8.6 +/- 0.5 vs. 3.3 +/- 0.3 micromol O(2).min(-1).g dry wt(-1), P < 0.001). V(Pyr) was higher in ATH than in SED (8.7 +/- 1.0 vs. 5.5 +/- 0.2 micromol O(2).min(-1).g dry wt(-1), P < 0.05), whereas V(PC) was not significantly different (5.3 +/- 0.9 vs. 4.4 +/- 0.5 micromol O(2).min(-1).g dry wt(-1)). V(S) was higher in ATH than in SED (11.0 +/- 0.6 vs. 6.0 +/- 0.3 micromol O(2).min(-1).g dry wt(-1), P < 0.001), as well as V(TMPD) (20.1 +/- 1.0 vs. 16.2 +/- 3.4 micromol O(2).min(-1).g dry wt(-1), P < 0.05). The ratios V(S)/V(GM) (1.3 +/- 0.1 vs. 2.0 +/- 0.1, P < 0.001) and V(TMPD)/V(GM) (2.4 +/- 1.0 vs. 5.2 +/- 1.8, P < 0.01) were lower in ATH than in SED. In conclusion, comparison of ATH vs. SED subjects suggests that regular endurance training at high intensity promotes the enhancement of maximal mitochondrial capacities to oxidize carbohydrate rather than fatty acid and induce specific adaptations of the mitochondrial respiratory chain at the level of complex I.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Nyckelord
- Sports Science
- Idrottsvetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Daussin, Frederi ...
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Zoll, Joffrey
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Ponsot, Elodie, ...
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Dufour, Stephane
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Doutreleau, Step ...
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Lonsdorfer, Evel ...
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Ventura-Clapier, ...
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Mettauer, Bertra ...
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Piquard, Francoi ...
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Geny, Bernard
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Richard, Ruddy
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- MEDICIN OCH HÄLSOVETENSKAP
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Örebro universitet