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  • Halfvarson, Jonas,1970-Division of Gastroenterology, Department of Internal Medicine, Örebro University Hospital, Örebro, Sweden (författare)

Anti-Saccharomyces cerevisiae antibodies in twins with inflammatory bowel disease

  • Artikel/kapitelEngelska2005

Förlag, utgivningsår, omfång ...

  • BMJ,2005
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-27380
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-27380URI
  • https://doi.org/10.1136/gut.2005.066860DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-33369URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND AND AIMS: An increased occurrence of anti-Saccharomyces cerevisiae antibodies (ASCA) is reported in unaffected members of families with Crohn's disease. Whether ASCA is a familial trait due to genetic factors or is caused by exposure to environmental factors is unknown. To assess the genetic influence of ASCA we studied its occurrence in a twin population.PATIENTS AND METHODS: ASCA were analysed in 98 twin pairs with inflammatory bowel disease and were related to clinical phenotype and CARD15/NOD2 genotype.RESULTS: ASCA were more common in Crohn's disease than in ulcerative colitis (40/70 (57%) twins v 5/43 (12%) twins). Associations with ileal Crohn's disease, stricturing/penetrating behaviour, and young age, but not CARD15/NOD2 were confirmed. ASCA were found in 1/20 (5%) healthy siblings in discordant monozygotic pairs with Crohn's disease compared with 7/27 (26%) in discordant dizygotic pairs. Using the intraclass correlation coefficient (ICC), no agreement in ASCA titres was observed in discordant twin pairs with Crohn's disease, in monozygotic (ICC = -0.02) or dizygotic (ICC = -0.26) pairs. In contrast, strong agreement was seen within concordant monozygotic twin pairs with Crohn's disease (ICC = 0.76).CONCLUSIONS: These findings question the concept of ASCA as a marker of genetic susceptibility for Crohn's disease. The agreement in ASCA titres within concordant monozygotic twin pairs with Crohn's disease, suggests that the level of increase is genetically determined. We propose that ASCA are a marker of a response to an environmental antigen and that a specific gene(s) other than CARD15/NOD2 determines the level of response and perhaps also specific phenotypic characteristics.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Standaert-Vitse, ALaboratoire de Mycologie Fondamentale and Appliquée, Inserm E360, Faculté de Médecine, CHU Lille, Lille, France (författare)
  • Järnerot, GDivision of Gastroenterology, Department of Internal Medicine, Örebro University Hospital, Örebro, Sweden (författare)
  • Sendid, BLaboratoire de Mycologie Fondamentale and Appliquée, Inserm E360, Faculté de Médecine, CHU Lille, Lille, France (författare)
  • Jouault, TLaboratoire de Mycologie Fondamentale and Appliquée, Inserm E360, Faculté de Médecine, CHU Lille, Lille, France (författare)
  • Bodin, LStatistical and Epidemiological Unit, Clinical Research Centre, Örebro University Hospital, Örebro, Sweden (författare)
  • Duhamel, ACentre d’Etudes et de Recherche en Informatique Médicale, Faculté de Médecine, CHU Lille, Lille, France (författare)
  • Colombel, J FDepartment of Hepatogastroenterology, Hopital Huriez, CHU Lille, Lille, France (författare)
  • Tysk, CDivision of Gastroenterology, Department of Internal Medicine, and Department of Clinical Medicine, Örebro University Hospital, Örebro, Sweden (författare)
  • Poulain, DLaboratoire de Mycologie Fondamentale and Appliquée, Inserm E360, Faculté de Médecine, CHU Lille, Lille, France (författare)
  • Division of Gastroenterology, Department of Internal Medicine, Örebro University Hospital, Örebro, SwedenLaboratoire de Mycologie Fondamentale and Appliquée, Inserm E360, Faculté de Médecine, CHU Lille, Lille, France (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Gut: BMJ54:9, s. 1237-12430017-57491468-3288

Internetlänk

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  • Gut (Sök värdpublikationen i LIBRIS)

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