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Livin expression is...
Livin expression is an independent factor in rectal cancer patients with or without preoperative radiotherapy
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- Ding, Zhen-Yu (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- Zhang, Hong, 1957- (author)
- Örebro universitet,Institutionen för läkarutbildning,University of Örebro, Sweden
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- Adell, Gunnar (author)
- Department of Oncology, Karolinska University Hospital, Stockholm, Sweden
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- Olsson, Birgit (author)
- Linköpings universitet,Onkologi,Hälsouniversitetet
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- Sun, Xiao-Feng (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Onkologiska kliniken US
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(creator_code:org_t)
- London, United Kingdom : BioMed Central, 2013
- 2013
- English.
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In: Radiation Oncology. - London, United Kingdom : BioMed Central. - 1748-717X. ; 8:1
- Related links:
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https://doi.org/10.1...
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: This study was aimed to investigate the expression significance of Livin in relation to radiotherapy (RT), clinicopathological and biological factors of rectal cancer patients.Methods: This study included 144 primary rectal cancer patients who participated in a Swedish clinical trial of preoperative radiotherapy. Tissue microarray samples from the excised primary rectal cancers, normal mucosa and lymph node metastases were immunostained with Livin antibody. The proliferation of colon cancer cell lines SW620 and RKO was assayed after Livin knock-down.Results: The expression of Livin was significantly increased from adjacent (P = 0.051) or distant (P = 0.028) normal mucosa to primary tumors. 15.4% (2/13) and 39.7% (52/131) patients with Livin-negative and positive tumors died at 180 months after surgery, and the difference tended to be statistically significant (P = 0.091). In multivariate analyses, the difference achieved statistical significance, independent of TNM stage, local and distant recurrence, grade of differentiation, gender, and age (odds ratio = 5.09, 95% CI: 1.01-25.64, P = 0.048). The in vitro study indicated colon cancer cells with Livin knock-down exhibited decreased proliferation compared with controls after RT.Conclusions: The expression of Livin was was independently related to survival in rectal cancer patients, suggesting Livin as a useful prognostic factor for rectal cancer patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Rectal cancer
- livin
- radiotherapy
- Onkologi
- Oncology
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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