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Coeliac disease and...
Coeliac disease and risk of renal disease : a general population cohort study
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- Ludvigsson, Jonas F. (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för klinisk medicin,Kliniskt ForskningsCentrum, Universitetssjukhuset, Örebro
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- Montgomery, Scott M. (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för klinisk medicin,Clinical Epidemiology Unit, Karolinska sjukhuset, Stockholm
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- Olén, Ola (författare)
- Karolinska Institutet,Avd för Pediatrik, Södersjukhuset, Stockholm
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- Ekbom, Anders (författare)
- Karolinska Institutet,Clinical Epidemiology Unit, Karolinska sjukhuset, Stockholm
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- Ludvigsson, Johnny, 1943- (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Pediatrik,Barn- och ungdomskliniken i Linköping
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- Fored, Michael (författare)
- Karolinska Institutet,Clinical Epidemiology Unit, Karolinska sjukhuset, Stockholm
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(creator_code:org_t)
- 2006-03-30
- 2006
- Engelska.
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Ingår i: Nephrology, Dialysis and Transplantation. - : Oxford University Press (OUP). - 0931-0509 .- 1460-2385. ; 21:7, s. 1809-1815
- Relaterad länk:
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https://doi.org/10.1...
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- BACKGROUND:Coeliac disease (CD) may be a risk factor for renal disease.METHODS:We investigated the risk of any form of glomerulonephritis (GN) (acute, chronic and non-specified), chronic glomerulonephritis (CGN) and renal replacement therapy including dialysis treatment and kidney transplantation (KT) in patients with CD in a general population-based cohort study. We used Cox regression to assess the risk of renal disease in 14,336 patients who had received a diagnosis of CD (1964-2003) and 69,875 reference individuals matched for age, calendar year, sex and county. Patients were identified using the Swedish Hospital Discharge Registry. Follow-up began 1 year after study entry.RESULTS:CD was associated with an increased risk of any form of GN (hazard ratio (HR) = 1.64; 95% confidence intervals (CI) = 1.01-2.66; P = 0.046; 89 events), CGN (HR = 2.65; 95% CI = 1.34-5.24; P = 0.005; 39 events), dialysis (HR = 3.48; 95% CI = 2.26-5.37; P < 0.001; 102 positive events) and KT (HR = 3.15; 95% CI = 1.29-7.71; P = 0.012; 22 events).CONCLUSION:We suggest that immune characteristics associated with CD increase the risk of chronic renal disease. Individuals with CD may also be at a moderately increased risk of any form of GN.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- Adolescent
- Adult
- Celiac Disease/*complications/*diagnosis
- Child
- Child; Preschool
- Cohort Studies
- Female
- Glomerulonephritis/metabolism
- Humans
- Infant
- Infant; Newborn
- Kidney Diseases/*complications/*diagnosis
- Kidney Transplantation
- Male
- Middle Aged
- Proportional Hazards Models
- Risk
- Risk Factors
- MEDICINE
- MEDICIN
- Internal medicine
- Invärtesmedicin
- Kidney diseases
- Njursjukdomar
- Invärtesmedicin
- Internal Medicine
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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