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Does Mortality Risk...
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Lee, Duk-HeeSch Med, Dept Prevent Med, Kyungpook Natl Univ, Taegu, South Korea; Dept Biomed Sci, Plus KNU Biomed Convergence Program BK21, Kyungpook Natl Univ, Taegu, South Korea
(författare)
Does Mortality Risk of Cigarette Smoking Depend on Serum Concentrations of Persistent Organic Pollutants? : Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) Study
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
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2014-05-14
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San Francisco :Public Library Science,2014
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-35836
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-35836URI
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https://doi.org/10.1371/journal.pone.0095937DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-228480URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Funding Agencies:Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS)Korea Health technology RD ProjectMinistry of Health & Welfare, Republic of KoreaBK21 PLUS KNU Biomedical Convergence Program for Creative Talent
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Cigarette smoking is an important cause of preventable death globally, but associations between smoking and mortality vary substantially across country and calendar time. Although methodological biases have been discussed, it is biologically plausible that persistent organic pollutants (POPs) like polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides can affect this association. This study was performed to evaluate if associations of cigarette smoking with mortality were modified by serum concentrations of PCBs and OC pesticides. We evaluated cigarette smoking in 111 total deaths among 986 men and women aged 70 years in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) with mean follow-up for 7.7 years. The association between cigarette smoking and total mortality depended on serum concentration of PCBs and OC pesticides (P value for interaction = 0.02). Among participants in the highest tertile of the serum POPs summary score, former and current smokers had 3.7 (95% CI, 1.5-9.3) and 6.4 (95% CI, 2.3-17.7) times higher mortality hazard, respectively, than never smokers. In contrast, the association between cigarette smoking and total mortality among participants in the lowest tertile of the serum POPs summary score was much weaker and statistically nonsignificant. The strong smoking-mortality association observed among elderly people with high POPs was mainly driven by low risk of mortality among never smokers with high POPs. As smoking is increasing in many low-income and middle-income countries and POPs contamination is a continuing problem in these areas, the interactions between these two important health-related issues should be considered in future research.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind
(författare)
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Jacobs, David R., Jr.Sch Publ Hlth, Div Epidemiol & Community Hlth, Univ Minnesota, Minneapolis MN, USA; Dept Nutr, Univ Oslo, Oslo, Norway
(författare)
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Salihovic, Samira,1985-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)sasc
(författare)
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van Bavel, Bert,1963-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)bvl
(författare)
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Lind, Monica P.Uppsala universitet,Arbets- och miljömedicin(Swepub:uu)monilind
(författare)
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Sch Med, Dept Prevent Med, Kyungpook Natl Univ, Taegu, South Korea; Dept Biomed Sci, Plus KNU Biomed Convergence Program BK21, Kyungpook Natl Univ, Taegu, South KoreaKardiovaskulär epidemiologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:PLOS ONESan Francisco : Public Library Science9:5, s. e95937-1932-6203
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