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SPINK1 protein expression and prostate cancer progression

Flavin, Richard (author)
Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Boston, USA; Departments of Medical Oncology, Dana Farber Cancer Institute, Boston, USA
Pettersson, Andreas (author)
Karolinska Institutet
Hendrickson, Whitney K. (author)
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
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Fiorentino, Michelangelo (author)
Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Boston, USA
Finn, Stephen (author)
Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Boston, USA; Department of Histopathology, St. James's Hospital, Trinity College Dublin Medical School, Dublin, Ireland
Kunz, Lauren (author)
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
Judson, Gregory L. (author)
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
Lis, Rosina (author)
Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Boston, USA
Bailey, Dyane (author)
Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Boston, USA
Fiore, Christopher (author)
Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Boston, USA
Nuttall, Elizabeth (author)
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
Martin, Neil E. (author)
Departments of Radiation Oncology, Dana Farber Cancer Institute, Boston, USA
Stack, Edward (author)
Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Boston, USA
Penney, Kathryn L. (author)
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
Rider, Jennifer R. (author)
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
Sinnott, Jennifer (author)
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
Sweeney, Christopher (author)
Departments of Medical Oncology, Dana Farber Cancer Institute, Boston, USA
Sesso, Howard D (author)
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, USA
Fall, Katja, 1971- (author)
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
Giovannucci, Edward (author)
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
Kantoff, Philip (author)
Departments of Medical Oncology, Dana Farber Cancer Institute, Boston, USA
Stampfer, Meir (author)
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
Loda, Massimo (author)
Center for Molecular Oncologic Pathology, Dana Farber Cancer Institute, Boston, USA; Departments of Medical Oncology, Dana Farber Cancer Institute, Boston, USA
Mucci, Lorelei A. (author)
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, USA; Department of Epidemiology, Harvard School of Public Health, Boston, USA
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 (creator_code:org_t)
Philadelphia, USA : American Association for Cancer Research, 2014
2014
English.
In: Clinical Cancer Research. - Philadelphia, USA : American Association for Cancer Research. - 1078-0432 .- 1557-3265. ; 20:18, s. 4904-11
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Purpose: SPINK1 overexpression has been described in prostate cancer and is linked with poor prognosis in many cancers. The objective of this study was to characterize the association between SPINK1 overexpression and prostate cancer-specific survival.Experimental design: The study included 879 participants in the U.S. Physicians' Health Study and Health Professionals Follow-Up Study, diagnosed with prostate cancer (1983-2004) and treated by radical prostatectomy. Protein tumor expression of SPINK1 was evaluated by immunohistochemistry on tumor tissue microarrays.Results: Seventy-four of 879 (8%) prostate cancer tumors were SPINK1 positive. Immunohistochemical data were available for PTEN, p-Akt, pS6, stathmin, androgen receptor (AR), and ERG (as a measure of the TMPRSS2:ERG translocation). Compared with SPINK1-negative tumors, SPINK1-positive tumors showed higher PTEN and stathmin expression, and lower expression of AR (P < 0.01). SPINK1 overexpression was seen in 47 of 427 (11%) ERG-negative samples and in 19 of 427 (4%) ERG-positive cases (P = 0.0003). We found no significant associations between SPINK1 status and Gleason grade or tumor stage. There was no association between SPINK1 expression and biochemical recurrence (P = 0.56). Moreover, there was no association between SPINK1 expression and prostate cancer mortality (there were 75 lethal cases of prostate cancer during a mean of 13.5 years follow-up; HR = 0.71; 95% confidence interval, 0.29-1.76).Conclusions: Our results suggest that SPINK1 protein expression may not be a predictor of recurrence or lethal prostate cancer amongst men treated by radical prostatectomy. SPINK1 and ERG protein expression do not seem to be entirely mutually exclusive, as some previous studies have suggested.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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