onr:"swepub:oai:DiVA.org:oru-41463"
Sökning: onr:"swepub:oai:DiVA.org:oru-41463" > No association betw...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04664naa a2200421 4500 | |
| 001 | oai:DiVA.org:oru-41463 | |
| 003 | SwePub | |
| 008 | 150114s2008 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:117549840 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-414632 URI |
| 024 | 7 | a https://doi.org/10.1002/pros.207972 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1175498402 URI |
| 040 | a (SwePub)orud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Fall, Katja,d 1971-u Karolinska Institutet4 aut0 (Swepub:oru)kafl |
| 245 | 1 0 | a No association between a polymorphic variant of the IRS-1 gene and prostate cancer risk |
| 264 | 1 | a Hoboken, USA :b John Wiley & Sons,c 2008 |
| 338 | a print2 rdacarrier | |
| 520 | a Objective: Insulin receptor substrate-1 (IRS-1) acts as a docking protein between the insulin-like growth factor-1 (IGF-1) receptor and intracellular signaling molecules in the IGF-1 signaling pathway. Accumulating data support a role of IGF-1 in prostate carcinogenesis. We assessed the influence of the most common IRS-1 gene polymorphism (Gly972Arg) on prostate cancer risk, alone and in combination with IGF-1 and other components in the IGF-1 signaling pathway.Materials and methods: In a nested case-control study within the Physicians' Health Study, the IRS-1 polymorphism was assayed from prospectively collected samples from 564 incident prostate cancer cases and 758 controls matched on age and smoking. We calculated relative risks (RR) and 95% confidence intervals (CI) using conditional logistic regression.Results: Among the controls, 0.8% were homozygous (AA) and 12% were heterozygous (GA) for the polymorphic allele. There was no association between carriage of the A allele and total prostate cancer risk (RR = 1.1 95% CI = 0.8-1.5), advanced disease (stage C or D or lethal prostate cancer, RR = 1.3 95% CI = 0.8-2.3), or plasma IGF-1 levels. We explored possible interactions with body mass index and components in the IGF-1 pathway including IGFBP3, PI3k, and PTEN but none of these factors influenced the relation between IRS-1 genotype and prostate cancer risk.Conclusions: Our data do not support an association between carriage of the variant IRS-1 gene and prostate cancer risk. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 700 | 1 | a Stark, J. R.u Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham Women’s Hospital and Harvard Medical School, Boston, USA4 aut |
| 700 | 1 | a Mucci, L. A.u Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA4 aut |
| 700 | 1 | a Chan, J.u Departments of Epidemiology & Biostatistics and Urology, University of California, San Francisco, USA4 aut |
| 700 | 1 | a Stampfer, M. J.u Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA4 aut |
| 700 | 1 | a Kurth, T.u Department of Epidemiology, Harvard School of Public Health, Boston, USA; Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA4 aut |
| 700 | 1 | a Febbo, P. G.u Duke University School of Medicine, Durham, USA4 aut |
| 700 | 1 | a Kantoff, P.u Division of Solid Tumor Oncology, Dana-Farber Cancer Institute, Boston, USA4 aut |
| 700 | 1 | a Ma, J.u Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA4 aut |
| 710 | 2 | a Karolinska Institutetb Department of Epidemiology, Harvard School of Public Health, Boston, USA; Channing Laboratory, Department of Medicine, Brigham Women’s Hospital and Harvard Medical School, Boston, USA4 org |
| 773 | 0 | t The Prostated Hoboken, USA : John Wiley & Sonsg 68:13, s. 1416-20q 68:13<1416-20x 0270-4137x 1097-0045 |
| 856 | 4 | u https://europepmc.org/articles/pmc2958090?pdf=render |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-41463 |
| 856 | 4 8 | u https://doi.org/10.1002/pros.20797 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:117549840 |
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Fall, Katja, 197 ...
- Stark, J. R.
- Mucci, L. A.
- Chan, J.
- Stampfer, M. J.
- Kurth, T.
- visa fler...
- Febbo, P. G.
- Kantoff, P.
- Ma, J.
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Cancer och onkol ...
- Artiklar i publikationen
- The Prostate
- Av lärosätet
- Örebro universitet
- Karolinska Institutet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
