Influence of GABA and GABA-producing Lactobacillus brevis DPC 6108 on the development of diabetes in a streptozotocin rat model

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Influence of GABA and GABA-producing Lactobacillus brevis DPC 6108 on the development of diabetes in a streptozotocin rat model

Marques, Tatiana M., 1980- (author): APC Microbiome Institute, University College Cork, Cork, Ireland; Moorepark, Teagasc Food Research Centre, Fermoy, Ireland; School of Microbiology, University College Cork, Cork, Ireland

Patterson, E. (author): APC Microbiome Institute, University College Cork, Cork, Ireland; Moorepark, Teagasc Food Research Centre, Fermoy, Ireland; School of Microbiology, University College Cork, Cork, Ireland

Wall, Rebecca, 1979- (author): APC Microbiome Institute, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Fermoy, Ireland

O'Sullivan, O. (author): APC Microbiome Institute, University College Cork, Cork, Ireland; Teagasc Food Research Centre Moorepark, Fermoy, Ireland

Fitzgerald, G. F. (author): APC Microbiome Institute, University College Cork, Cork, Ireland; School of Microbiology, University College Cork, Cork, Ireland

Cotter, P. D. (author): APC Microbiome Institute, University College Cork, Cork, Ireland; Teagasc Food Research Centre Moorepark, Fermoy, Ireland

Dinan, T. G. (author): APC Microbiome Institute, University College Cork, Cork, Ireland; School of Microbiology, University College Cork, Cork, Ireland

Cryan, J. F. (author): APC Microbiome Institute, University College Cork, Cork, Ireland

Ross, R. P. (author): APC Microbiome Institute, University College Cork, Cork, Ireland

Stanton, C. (author): APC Microbiome Institute, University College Cork, Cork, Ireland; Teagasc Food Research Centre Moorepark, Fermoy, Ireland

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Wageningen, Netherlands : Wageningen Academic Publishers, 2016
2016
English.
In: Beneficial Microbes. - Wageningen, Netherlands : Wageningen Academic Publishers. - 1876-2883 .- 1876-2891. ; 7:3, s. 409-420

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.3...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

The aim of this study was to investigate if dietary administration of γ-aminobutyric acid (GABA)-producing Lactobacillus brevis DPC 6108 and pure GABA exert protective effects against the development of diabetes in streptozotocin (STZ)-induced diabetic Sprague Dawley rats. In a first experiment, healthy rats were divided in 3 groups (n=10/group) receiving placebo, 2.6 mg/kg body weight (bw) pure GABA or L. brevis DPC 6108 (~10(9)microorganisms). In a second experiment, rats (n=15/group) were randomised to five groups and four of these received an injection of STZ to induce type 1 diabetes. Diabetic and non-diabetic controls received placebo [4% (w/v) yeast extract in dH2O], while the other three diabetic groups received one of the following dietary supplements: 2.6 mg/kg bw GABA (low GABA), 200 mg/kg bw GABA (high GABA) or ~10(9) L. brevis DPC 6108. L. brevis DPC 6108 supplementation was associated with increased serum insulin levels (P<0.05), but did not alter other metabolic markers in healthy rats. Diabetes induced by STZ injection decreased body weight (P<0.05), increased intestinal length (P<0.05) and stimulated water and food intake. Insulin was decreased (P<0.05), whereas glucose was increased (P<0.001) in all diabetic groups, compared with non-diabetic controls. A decrease (P<0.01) in glucose levels was observed in diabetic rats receiving L. brevis DPC 6108, compared with diabetic-controls. Both the composition and diversity of the intestinal microbiota were affected by diabetes. Microbial diversity in diabetic rats supplemented with low GABA was not reduced (P>0.05), compared with non-diabetic controls while all other diabetic groups displayed reduced diversity (P<0.05). L. brevis DPC 6108 attenuated hyperglycaemia induced by diabetes but additional studies are needed to understand the mechanisms involved in this reduction.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Keyword

Streptozotocin
type-1 diabetes
probiotic
γ-aminobutyric acid

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ref (subject category)
art (subject category)

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By the author/editor: Marques, Tatiana ...; Patterson, E.; Wall, Rebecca, 1 ...; O'Sullivan, O.; Fitzgerald, G. F ...; Cotter, P. D.; show more...; Dinan, T. G.; Cryan, J. F.; Ross, R. P.; Stanton, C.; show less...

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