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Stimulant and non-s...
Stimulant and non-stimulant attention deficit/hyperactivity disorder drug use : total population study of trends and discontinuation patterns 2006-2009
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- Zetterqvist, J. (author)
- Karolinska Institutet
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- Asherson, P. (author)
- MRC Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, Kings College London, London, UK
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- Halldner, L (author)
- Karolinska Institutet
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- Långström, N. (author)
- Karolinska Institutet
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- Larsson, Henrik, 1975- (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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(creator_code:org_t)
- 2012-09-04
- 2013
- English.
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In: Acta Psychiatrica Scandinavica. - Hoboken, USA : Wiley-Blackwell. - 0001-690X .- 1600-0447. ; 128:1, s. 70-77
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objective: To explore the prevalence and discontinuation of dispensed medications for attention deficit/hyperactivity disorder (ADHD) drugs from 2006 to 2009.Method: A total population cohort of all individuals aged 6-45 years, alive and registered as residents in Sweden during any calendar year from 2006 to 2009 (N = 5 149 791) included 41 700 patients dispensed with an ADHD drug (methylphenidate, atomoxetine, amphetamine, or dexamphetamine). The dispensing prevalence was calculated for each year, stratified on sex and age. A longitudinal analysis was also performed to compare the rates of treatment discontinuation across the strata.Results: The dispensing prevalence increased from 2.93 per 1000 in 2006 to 6.98 in 2009 (PR = 2.38, 95% CI = 2.34-2.43). The prevalence ratio (PR) was 3.40 for adults, 22-45 years old; 2.41 for adolescents, 15-21 years old; and 1.90 for children aged 6-14. The increase was also greater in women than in men (PR = 2.92 vs. 2.19). Patients aged 15-21 were the most likely to discontinue treatment; after 3 years and 11 months, 27% of those patients were still under treatment.Conclusion: From 2006 to 2009, the number of prescriptions dispensed for ADHD drugs increased substantially. The rate of treatment discontinuation in the age interval 15-21 is higher than expected considering the persistence rates of the disorder.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Attention deficit ⁄ hyperactivity disorder
- pharmacoepidemiology
- psychostimulants
- treatment
Publication and Content Type
- ref (subject category)
- art (subject category)
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