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A Genetically Infor...
A Genetically Informed Study of the Associations Between Maternal Age at Childbearing and Adverse Perinatal Outcomes
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- Sujan, Ayesha C. (author)
- Department of Psychological and Brain Sciences, Indiana University, Bloomington, USA
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- Rickert, Martin E. (author)
- Department of Psychological and Brain Sciences, Indiana University, Bloomington, USA
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- Class, Quetzal A. (author)
- Karolinska Institutet
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- Coyne, Claire A. (author)
- Ann and Robert H. Lurie Children’s Hospital, Chicago, USA
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- Lichtenstein, Paul (author)
- Karolinska Institutet
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- Almqvist, Catarina (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Astrid Lindgren Children’s Hospital, Karolinska University Hospital, Stockholm, Sweden
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- Larsson, Henrik, 1975- (author)
- Karolinska Institutet
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- Sjölander, Arvid (author)
- Karolinska Institutet
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- Lahey, Benjamin B. (author)
- Department of Public Health Sciences, University of Chicago, Chicago, USA
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- van Hulle, Carol (author)
- Waisman Center, University of Wisconsin, Madison, USA
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- Waldman, Irwin (author)
- Department of Psychology, Emory University, Atlanta, USA
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- Öberg, A. Sara (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA
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- D'Onofrio, Brian M. (author)
- Karolinska Institutet
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- ISSN 0001-8244
- 2015-09-24
- 2016
- English.
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In: Behavior Genetics. - New York, USA : Springer. - 0001-8244 .- 1573-3297. ; 46:3, s. 431-456
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Abstract
Subject headings
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- We examined associations of maternal age at childbearing (MAC) with gestational age and fetal growth (i.e., birth weight adjusting for gestational age), using two genetically informed designs (cousin and sibling comparisons) and data from two cohorts, a population-based Swedish sample and a nationally representative United States sample. We also conducted sensitivity analyses to test limitations of the designs. The findings were consistent across samples and suggested that, associations observed in the population between younger MAC and shorter gestational age were confounded by shared familial factors; however, associations of advanced MAC with shorter gestational age remained robust after accounting for shared familial factors. In contrast to the gestational age findings, neither early nor advanced MAC was associated with lower fetal growth after accounting for shared familial factors. Given certain assumptions, these findings provide support for a causal association between advanced MAC and shorter gestational age. The results also suggest that there are not causal associations between early MAC and shorter gestational age, between early MAC and lower fetal growth, and between advanced MAC and lower fetal growth.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Keyword
- Gestational age
- birth weight
- fetal growth
- maternal age at childbearing
- genetically informed designs
- quasi-experiments
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Sujan, Ayesha C.
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Rickert, Martin ...
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Class, Quetzal A ...
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Coyne, Claire A.
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Lichtenstein, Pa ...
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Almqvist, Catari ...
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show more...
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Larsson, Henrik, ...
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Sjölander, Arvid
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Lahey, Benjamin ...
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van Hulle, Carol
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Waldman, Irwin
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Öberg, A. Sara
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D'Onofrio, Brian ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
- Articles in the publication
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Behavior Genetic ...
- By the university
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Örebro University
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Karolinska Institutet