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Sökning: onr:"swepub:oai:DiVA.org:oru-68145" > Public health surve...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007129naa a2200493 4500
001oai:DiVA.org:oru-68145
003SwePub
008180726s2018 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-681452 URI
0247 a https://doi.org/10.1016/S1473-3099(18)30225-12 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Harris, Simon R.u Infection Genomics, Wellcome Sanger Institute, Hinxton, United Kingdom4 aut
2451 0a Public health surveillance of multidrug-resistant clones of Neisseria gonorrhoeae in Europe :b a genomic survey
264 1b Elsevier,c 2018
338 a print2 rdacarrier
500 a Funding Agencies:European Centre for Disease Prevention and Control  Centre for Genomic Pathogen Surveillance  Örebro University Hospital  Wellcome 
520 a Background: Traditional methods for molecular epidemiology of Neisseria gonorrhoeae are suboptimal. Whole-genome sequencing (WGS) offers ideal resolution to describe population dynamics and to predict and infer transmission of antimicrobial resistance, and can enhance infection control through linkage with epidemiological data. We used WGS, in conjunction with linked epidemiological and phenotypic data, to describe the gonococcal population in 20 European countries. We aimed to detail changes in phenotypic antimicrobial resistance levels (and the reasons for these changes) and strain distribution (with a focus on antimicrobial resistance strains in risk groups), and to predict antimicrobial resistance from WGS data.Methods: We carried out an observational study, in which we sequenced isolates taken from patients with gonorrhoea from the European Gonococcal Antimicrobial Surveillance Programme in 20 countries from September to November, 2013. We also developed a web platform that we used for automated antimicrobial resistance prediction, molecular typing (N gonorrhoeae multi-antigen sequence typing [NG-MAST] and multilocus sequence typing), and phylogenetic clustering in conjunction with epidemiological and phenotypic data.Findings: The multidrug-resistant NG-MAST genogroup G1407 was predominant and accounted for the most cephalosporin resistance, but the prevalence of this genogroup decreased from 248 (23%) of 1066 isolates in a previous study from 2009-10 to 174 (17%) of 1054 isolates in this survey in 2013. This genogroup previously showed an association with men who have sex with men, but changed to an association with heterosexual people (odds ratio=4.29). WGS provided substantially improved resolution and accuracy over NG-MAST and multilocus sequence typing, predicted antimicrobial resistance relatively well, and identified discrepant isolates, mixed infections or contaminants, and multidrug-resistant clades linked to risk groups.Interpretation: To our knowledge, we provide the first use of joint analysis of WGS and epidemiological data in an international programme for regional surveillance of sexually transmitted infections. WGS provided enhanced understanding of the distribution of antimicrobial resistance clones, including replacement with clones that were more susceptible to antimicrobials, in several risk groups nationally and regionally. We provide a framework for genomic surveillance of gonococci through standardised sampling, use of WGS, and a shared information architecture for interpretation and dissemination by use of open access software.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
7001 a Cole, Michelle J.u Antimicrobial Resistance and Healthcare Associated Infections Reference Unit, National Infection Service, Public Health England, London, United Kingdom4 aut
7001 a Spiteri, Gianfrancou European Centre for Disease Prevention and Control, Stockholm, Sweden4 aut
7001 a Sanchez-Buso, Leonoru Infection Genomics, Wellcome Sanger Institute, Hinxton, United Kingdom4 aut
7001 a Golparian, Daniel,d 1984-u Örebro universitet,Institutionen för medicinska vetenskaper,WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)degn
7001 a Jacobsson, Susanne,d 1974-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)sajn
7001 a Goater, Richardu Centre for Genomic Pathogen Surveillance, Wellcome Sanger Institute, Hinxton, United Kingdom4 aut
7001 a Abudahab, Khalilu Centre for Genomic Pathogen Surveillance, Wellcome Sanger Institute, Hinxton, United Kingdom4 aut
7001 a Yeats, Corin A.u Centre for Genomic Pathogen Surveillance, Wellcome Sanger Institute, Hinxton, United Kingdom4 aut
7001 a Bercot, Beatriceu St Louis Hospital, Assistance Publique Hôpitaux de Paris (APHP), Paris, France4 aut
7001 a Borrego, Maria Joseu National Institute of Health, Lisbon, Portugal4 aut
7001 a Crowley, Brendanu St James's Hospital, Dublin, Ireland4 aut
7001 a Stefanelli, Paolau Istituto Superiore di Sanitá, Rome, Italy4 aut
7001 a Tripodo, Francescou Antimicrobial Resistance and Healthcare Associated Infections Reference Unit, National Infection Service, Public Health England, London, United Kingdom4 aut
7001 a Abad, Raquelu Carlos III Health Institute, Madrid, Spain4 aut
7001 a Aanensen, David M.u Centre for Genomic Pathogen Surveillance, Wellcome Sanger Institute, Hinxton, United Kingdom; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom4 aut
7001 a Unemo, Magnus,d 1970-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University Hospital, Örebro, Sweden4 aut0 (Swepub:oru)muo
7102 a Infection Genomics, Wellcome Sanger Institute, Hinxton, United Kingdomb Antimicrobial Resistance and Healthcare Associated Infections Reference Unit, National Infection Service, Public Health England, London, United Kingdom4 org
7730 t The Lancet - Infectious diseasesd : Elsevierg 18:7, s. 758-768q 18:7<758-768x 1473-3099x 1474-4457
8564 u https://doi.org/10.1016/S1473-3099(18)30225-1y Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-68145
8564 8u https://doi.org/10.1016/S1473-3099(18)30225-1

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