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Development of an I...
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Milton, A.Karolinska Institutet
(author)
Development of an ICU discharge instrument predicting psychological morbidity : a multinational study
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-11-22
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Springer,2018
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:oru-70858
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-70858URI
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https://doi.org/10.1007/s00134-018-5467-3DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-154009URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-372772URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:139797123URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies:ALF Funding Olle Engqvist Byggmästare Foundation
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Purpose: To develop an instrument for use at ICU discharge for prediction of psychological problems in ICU survivors.Methods: Multinational, prospective cohort study in ten general ICUs in secondary and tertiary care hospitals in Sweden, Denmark and the Netherlands. Adult patients with an ICU stay12h were eligible for inclusion. Patients in need of neurointensive care, with documented cognitive impairment, unable to communicate in the local language, without a home address or with more than one limitation of therapy were excluded. Primary outcome was psychological morbidity 3months after ICU discharge, defined as Hospital Anxiety and Depression Scale (HADS) subscale score11 or Post-traumatic Stress Symptoms Checklist-14 (PTSS-14) part B score>45.Results: A total of 572 patients were included and 78% of patients alive at follow-up responded to questionnaires. Twenty percent were classified as having psychological problems post-ICU. Of 18 potential risk factors, four were included in the final prediction model after multivariable logistic regression analysis: symptoms of depression [odds ratio (OR) 1.29, 95% confidence interval (CI) 1.10-1.50], traumatic memories (OR 1.44, 95% CI 1.13-1.82), lack of social support (OR 3.28, 95% CI 1.47-7.32) and age (age-dependent OR, peak risk at age 49-65years). The area under the receiver operating characteristics curve (AUC) for the instrument was 0.76 (95% CI 0.70-0.81).Conclusions: We developed an instrument to predict individual patients' risk for psychological problems 3months post-ICU, http://www.imm.ki.se/biostatistics/calculators/psychmorb/. The instrument can be used for triage of patients for psychological ICU follow-up.Trial registration: The study was registered at clinicaltrials.gov, NCT02679157.
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Schandl, A.Karolinska Institutet
(author)
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Soliman, I. W.Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands,Univ Utrecht, Univ Med Ctr Utrecht, Dept Intens Care Med, Utrecht, Netherlands
(author)
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Meijers, K.Department of Anaesthesiology and Intensive Care, Södersjukhuset, Stockholm, Sweden,Soder Sjukhuset, Dept Anaesthesiol & Intens Care, Stockholm, Sweden
(author)
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van den Boogaard, M.Department of Intensive Care Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands,Radboud Univ Nijmegen, Med Ctr, Dept Intens Care Med, Nijmegen, Netherlands
(author)
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Larsson, Ing-Marie,1963-Uppsala universitet,Anestesiologi och intensivvård(Swepub:uu)ingla697
(author)
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Brorsson, CamillaUmeå universitet,Anestesiologi och intensivvård,Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden(Swepub:umu)brca0001
(author)
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Östberg, U.Department of Anaesthesiology and Intensive Care, Östersund Hospital, Östersund, Sweden,Ostersund Hosp, Dept Anaesthesiol & Intens Care, Ostersund, Sweden
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Oxenbøll-Collet, M.Department of Intensive Care, Rigshospitalet Copenhagen, Copenhagen, Denmark,Rigshosp Copenhagen, Dept Intens Care, Copenhagen, Denmark
(author)
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Savilampi, Johanna,1977-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Anaesthesiology and Intensive Care, Örebro University Hospital, Örebro, Sweden,Orebro Univ Hosp, Dept Anaesthesiol & Intens Care, Orebro, Sweden(Swepub:oru)jsi
(author)
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Paskins, S.Department of Intensive Care, Odense University Hospital, Odense, Denmark,Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden,Odense Univ Hosp, Dept Intens Care, Odense, Denmark,Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden
(author)
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Bottai, M.Karolinska Institutet
(author)
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Sackey, P. V.Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
(author)
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Karolinska InstitutetDepartment of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands
(creator_code:org_t)
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In:Intensive Care Medicine: Springer44:12, s. 2038-20470342-46421432-1238
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