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Cord-Blood Lipidome...
Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes
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- Lamichhane, Santosh (författare)
- Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
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- Ahonen, Linda (författare)
- Steno Diabetes Center Copenhagen, Gentofte, Denmark
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- Dyrlund, Thomas Sparholt (författare)
- Steno Diabetes Center Copenhagen, Gentofte, Denmark
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- Dickens, Alex M (författare)
- Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
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- Siljander, Heli (författare)
- Children's Hospital, University of Helsinki, Helsinki University Hospital and Research Program Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland
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- Hyöty, Heikki (författare)
- Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland; Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland
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- Ilonen, Jorma (författare)
- Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland; Clinical Microbiology, Turku University Hospital, Turku, Finland
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- Toppari, Jorma (författare)
- Institute of Biomedicine, Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland; Department of Pediatrics, Turku University Hospital, Turku, Finland
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- Veijola, Riitta (författare)
- Department of Pediatrics, PEDEGO Research Unit, Medical Research Centre, University of Oulu, Oulu, Finland; Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
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- Hyötyläinen, Tuulia, 1971- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Knip, Mikael (författare)
- Children's Hospital, University of Helsinki, Helsinki University Hospital and Research Program Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland; Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland; Folkhälsan Research Center, Helsinki, Finland
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- Oresic, Matej, 1967- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
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(creator_code:org_t)
- 2019-01-21
- 2019
- Engelska.
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Ingår i: Biomolecules. - : MDPI. - 2218-273X. ; 9:1
- Relaterad länk:
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https://doi.org/10.3...
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Previous studies suggest that children who progress to type 1 diabetes (T1D) later in life already have an altered serum lipid molecular profile at birth. Here, we compared cord blood lipidome across the three study groups: children who progressed to T1D (PT1D; n = 30), children who developed at least one islet autoantibody but did not progress to T1D during the follow-up (P1Ab; n = 33), and their age-matched controls (CTR; n = 38). We found that phospholipids, specifically sphingomyelins, were lower in T1D progressors when compared to P1Ab and the CTR. Cholesterol esters remained higher in PT1D when compared to other groups. A signature comprising five lipids was predictive of the risk of progression to T1D, with an area under the receiver operating characteristic curve (AUROC) of 0.83. Our findings provide further evidence that the lipidomic profiles of newborn infants who progress to T1D later in life are different from lipidomic profiles in P1Ab and CTR.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Autoimmunity
- cord blood
- lipidomics
- metabolomics
- type 1 diabetes
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lamichhane, Sant ...
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Ahonen, Linda
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Dyrlund, Thomas ...
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Dickens, Alex M
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Siljander, Heli
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Hyöty, Heikki
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Ilonen, Jorma
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Toppari, Jorma
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Veijola, Riitta
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Hyötyläinen, Tuu ...
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Knip, Mikael
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Oresic, Matej, 1 ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Biomolecules
- Av lärosätet
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Örebro universitet
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Karolinska Institutet