onr:"swepub:oai:DiVA.org:oru-73147"
Sökning: onr:"swepub:oai:DiVA.org:oru-73147" > Studies of platelet...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
- Kardeby, Caroline,1989-Örebro universitet,Institutionen för medicinska vetenskaper (författare)
Studies of platelet signalling and endothelial cell responses using unique synthetic drugs
- BokEngelska2019
Förlag, utgivningsår, omfång ...
- Örebro :Örebro University,2019
- 64 s.
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:oru-73147
- ISBN:9789175292878
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-73147URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Serie
- Örebro Studies in Medicine,1652-4063 ;195
Anmärkningar
- Haemostasis is a complex and tightly regulated process which protects us from bleeding. Platelets are essential for maintained haemostasis. Under normal conditions platelets are calmed by antithrombotic substances release by the endothelium. During vascular injury, the platelets will activate and form a haemostatic plug to prevent bleeding. Inflammatory processes like atherosclerosis can disturb the haemostatic balance and lead to severe consequences like myocardial infarction and stroke. Inhibition of platelets and coagulation are common treatments to prevent unwanted blood clot formation. There is a great need for increased knowledge on the mechanisms of thrombosis and characterisation of new substances with possible therapeutic potential. This thesis used unique synthetic drugs to study platelet signalling and endothelial responses. Paper I showed that both sulfated polysaccharides from seaweed and synthetic glycopolymers which mimic their chemical properties caused platelet activation.Paper II elucidated the molecular mechanism underlying platelet activation by sulfated glycopolymers and polysaccharides. We found that human platelet activation took place via the Platelet endothelial aggregation receptor 1 (PEAR1), while mouse platelet activation was mainly via C-type lectin-like receptor 2. Aggregation was supported by Glycoprotein Ibα in both species.Paper III showed the effect of synthetic glycopolymers and natural polysaccharides on cultured human endothelial cells. We found that both the glycopolymers and polysaccharides caused a proinflammatory response after 24h.In Paper IV, the effect of a synthetic purine analogue with a nitrate ester motif was studied. We found that the purine analogue reduced platelet functions by inhibiting Rho-associated protein kinase (ROCK).This thesis describes unique synthetic drugs that can be used for further studies of the mechanisms underlying the biological processes of thrombosis and inflammation. The synthetic glycopolymers can be used to further elucidate the physiological role of PEAR1, a potential future therapeutic target.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Andra medicinska och farmaceutiska grundvetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Other Basic Medicine hsv//eng
- Haemostasis
- glycopolymers
- purine analogue
- PEAR1
- GPIbα
- CLEC-2
- inflammation
- ROCK
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Grenegård, Magnus,professor,1963-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)mgd (preses)
- Fälker, Knut,1971-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)ktfr (preses)
- Ljungberg, Liza,1980-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)lzlg (preses)
- Poole, Alastair W.,professorUniversity of Bristol (opponent)
- Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)
Internetlänk
- https://oru.diva-portal.org/smash/get/diva2:1296231/PREVIEW01.pngpreview image
- https://oru.diva-portal.org/smash/get/diva2:1296231/COVER01.pdfcover
- https://oru.diva-portal.org/smash/get/diva2:1296231/FULLTEXT01.pdffulltext
- https://oru.diva-portal.org/smash/get/diva2:1296231/SPIKBLAD01.pdfspikblad
- https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-73147
Hitta via bibliotek
- Studies of platelet signalling and endothelial cell responses using unique synth... (Sök publikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Kardeby, Carolin ...
- Grenegård, Magnu ...
- Fälker, Knut, 19 ...
- Ljungberg, Liza, ...
- Poole, Alastair ...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Medicinska och f ...
- och Andra medicinska ...
- Delar i serien
- Örebro Studies i ...
- Av lärosätet
- Örebro universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
