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A population-based ...
A population-based family clustering study of tic-related obsessive-compulsive disorder
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- Brander, Gustaf (author)
- Karolinska Institutet
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- Kuja-Halkola, Ralf (author)
- Karolinska Institutet
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- Rosenqvist, Mina A. (author)
- Karolinska Institutet
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- Rück, Christian (author)
- Karolinska Institutet
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- Serlachius, Eva (author)
- Karolinska Institutet
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- Fernández de la Cruz, Lorena (author)
- Karolinska Institutet
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- Lichtenstein, Paul (author)
- Karolinska Institutet
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- Crowley, James J. (author)
- Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
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- Larsson, Henrik, 1975- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Mataix-Cols, David (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2019-10-15
- 2021
- English.
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In: Molecular Psychiatry. - : Nature Publishing Group. - 1359-4184 .- 1476-5578. ; 26:4, s. 1224-1233
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Abstract
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- In the latest edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), obsessive-compulsive disorder (OCD) included a new "tic-related" specifier. However, strong evidence supporting tic-related OCD as a distinct subtype of OCD is lacking. This study investigated whether, at the population level, tic-related OCD has a stronger familial load than non-tic-related OCD. From a cohort of individuals born in Sweden between 1967 and 2007 (n = 4,085,367; 1257 with tic-related OCD and 20,975 with non-tic-related OCD), we identified all twins, full siblings, maternal and paternal half siblings, and cousins. Sex- and birth year-adjusted hazard ratios (aHR) were calculated to estimate the risk of OCD in relatives of individuals with OCD with and without comorbid tics, compared with relatives of unaffected individuals. We found that OCD is a familial disorder, regardless of comorbid tic disorder status. However, the risk of OCD in relatives of individuals with tic-related OCD was considerably greater than the risk of OCD in relatives of individuals with non-tic-related OCD (e.g., risk for full siblings: aHR = 10.63 [95% CI, 7.92-14.27] and aHR = 4.52 [95% CI, 4.06-5.02], respectively; p value for the difference < 0.0001). These differences remained when the groups were matched by age at first OCD diagnosis and after various sensitivity analyses. The observed familial patterns of OCD in relation to tics were not seen in relation to other neuropsychiatric comorbidities. Tic-related OCD is a particularly familial subtype of OCD. The results have important implications for ongoing gene-searching efforts.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Brander, Gustaf
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Kuja-Halkola, Ra ...
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Rosenqvist, Mina ...
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Rück, Christian
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Serlachius, Eva
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Fernández de la ...
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show more...
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Lichtenstein, Pa ...
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Crowley, James J ...
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Larsson, Henrik, ...
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Mataix-Cols, Dav ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Molecular Psychi ...
- By the university
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Örebro University
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Karolinska Institutet