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Co-aggregation and ...
Co-aggregation and heritability of organ-specific autoimmunity : a population-based twin study
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- Skov, Jakob (författare)
- Karolinska Institutet
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- Eriksson, Daniel (författare)
- Karolinska Institutet
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- Kuja-Halkola, Ralf (författare)
- Karolinska Institutet
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- Höijer, Jonas (författare)
- Uppsala universitet,Ortopedi
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- Gudbjörnsdottir, Soffia (författare)
- Departent of Molecular & Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; Swedish National Diabetes Register, Västra Götalandsregionen, Gothenburg, Sweden,Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden.;Swedish Natl Diabet Register, Gothenburg, Sweden.
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- Svensson, Ann-Marie (författare)
- Swedish National Diabetes Register, Västra Götalandsregionen, Gothenburg, Sweden,Swedish Natl Diabet Register, Gothenburg, Sweden.
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- Magnusson, Patrik K. E. (författare)
- Karolinska Institutet
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- Ludvigsson, Jonas F., 1969- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of pediatrics, Örebro University Hospital, Örebro, Sweden,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Orebro Univ Hosp, Dept Pediat, Orebro, Sweden.
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- Kämpe, Olle (författare)
- Karolinska Institutet
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- Bensing, Sophie (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Bioscientifica, 2020
- 2020
- Engelska.
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Ingår i: European Journal of Endocrinology. - : Bioscientifica. - 0804-4643 .- 1479-683X. ; 182:5, s. 473-480
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
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- Objective: Co-aggregation of autoimmune diseases is common, suggesting partly shared etiologies. Genetic factors are believed to be important, but objective measures of environ mental vs heritable influences on co-aggregation are absent. With a novel approach to twin studies, we aimed at estimating heritability and genetic overlap in seven organspecific autoimmune diseases.Design: Prospective twin cohort study.Methods: We used a cohort of 110 814 twins to examine co-aggregation and heritability of Hashimoto's thyroiditis, atrophic gastritis, celiac disease, Graves' disease, type 1 diabetes, vitiligo and Addison's disease. Hazard ratios (HR) were calculated for twins developing the same or different disease as compared to their co-twin. The differences between monozygotic and dizygotic twin pairs were used to estimate the genetic influence on co-aggregation. Heritability for individual disorders was calculated using structural equational modeling adjusting for censoring and truncation of data.Results: Co-aggregation was more pronounced in monozygotic twins (media n HR: 3.2, range: 2.2-9.2) than in dizygotic twins (median HR: 2.4, range: 1.1-10.0). Heritability was moderate for atrophic gastritis (0.38, 95% CI: 0.23-0.53) but high for all other diseases, ranging from 0.60 (95% CI: 0.49-0. 71) for Graves' disease to 0.97 (95% CI: 0.91- 1.00) for Addison's disease.Conclusions: Overall, co-aggregation was more pronounced in monozygotic than in dizygotic twins, suggesting that disease overlap is largely attributable to genetic factors. Co-aggregation was common, and twins faced up to a ten-fold risk of developing diseases not present in their co-twin. Our results validate and refine previous heritability estimates based on smaller twin cohorts.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Skov, Jakob
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Eriksson, Daniel
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Kuja-Halkola, Ra ...
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Höijer, Jonas
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Gudbjörnsdottir, ...
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Svensson, Ann-Ma ...
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visa fler...
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Magnusson, Patri ...
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Ludvigsson, Jona ...
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Kämpe, Olle
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Bensing, Sophie
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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European Journal ...
- Av lärosätet
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Örebro universitet
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Uppsala universitet
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Karolinska Institutet