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The association bet...
The association between control of interference and white-matter integrity : A cross-sectional and longitudinal investigation
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- Andersson, Pernilla, 1992- (author)
- Örebro universitet,Institutionen för juridik, psykologi och socialt arbete,Center for Lifespan Developmental Research (LEADER)
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- Li, Xin (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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- Persson, Jonas, 1971- (author)
- Karolinska Institutet,Stockholms universitet,Örebro universitet,Institutionen för juridik, psykologi och socialt arbete,Center for Lifespan Developmental Research (LEADER),Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Örebro University, Sweden
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Neurobiology of Aging. - : Elsevier. - 0197-4580 .- 1558-1497. ; 114, s. 49-60
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Abstract
Subject headings
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- Proactive interference (PI) occurs when old information interferes with newly acquired information and has been suggested as a major cause of forgetting in working memory. In this study, we investigate cross-sectional (N = 267) and longitudinal (N = 148) associations between PI and white-matter integrity (WMI) using diffusion-weighted imaging in an adult life-span sample (25-80 years; Mage = 60.15; 138 female). Older age was related to higher PI and lower WMI. Cross-sectional analyses showed associations between PI and WMI spanning several white-matter tracts as well as globally, suggesting that the age-related decline in PI may be driven primarily by global changes in WMI. Furthermore, longitudinal changes in PI were shown to be negatively correlated with concurrent changes in WMI in the fornix. Mediation analyses showed that WMI mediated the relationship between age and PI only in older adults, indicating that WMI becomes increasingly connected to cognitive functioning with increasing age. This is the first demonstration of WMI decline contributing to the age-related decline in PI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- Aging
- Cognition
- Diffusion weighted imaging
- Proactive interference
- White matter
Publication and Content Type
- ref (subject category)
- art (subject category)
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