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An antibiofilm coat...
An antibiofilm coating of 5-aryl-2-aminoimidazole covalently attached to a titanium surface
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- Peeters, Elien (författare)
- KU Leuven, Belgium
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- Hooyberghs, Geert (författare)
- KU Leuven, Belgium
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- Robijns, Stijn (författare)
- KU Leuven, Belgium
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- De Weerdt, Ami (författare)
- KU Leuven, Belgium
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- Kucharíková, Sona (författare)
- KU Leuven, Belgium
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- Tournu, Helene (författare)
- KU Leuven, Belgium
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- Braem, Annabel (författare)
- KU Leuven, Belgium
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- Čeh, Katerina (författare)
- University of Ljubljana, Slovenia
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- Majdic, Gregor (författare)
- University of Ljubljana, Slovenia
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- Španič, Tanja (författare)
- University of Ljubljana, Slovenia
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- Pogorevc, Estera (författare)
- University of Ljubljana, Slovenia
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- Claes, Birgit (författare)
- KU Leuven, Belgium
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- Dovgan, Barbara (författare)
- Educell Ltd, Slovenia
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- Girandon, Lenart (författare)
- Educell Ltd, Slovenia
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- Impellizzeri, Frederic (författare)
- Biotech International, France
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- Erdtmann, Martin (författare)
- Hemoteq AG, Germany
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- Krona, Annika (författare)
- RISE,Jordbruk och livsmedel
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- Vleugels, Jef (författare)
- KU Leuven, Belgium
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- Fröhlich, Mirjan (författare)
- University of Ljubljana, Slovenia
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- Garcia-Forgas, Jordi (författare)
- Alhenia AG, Switzerland
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- De Brucker, Katrijn (författare)
- KU Leuven, Belgium
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- Cammue, Bruno (författare)
- VIB Center for Plant Systems Biology, Belgium; KU Leuven, Belgium
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- Thevissen, Karin (författare)
- KU Leuven, Belgium
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- Van Dijck, Patrick (författare)
- KU Leuven, Belgium
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- Vanderleyden, Jozef (författare)
- KU Leuven, Belgium
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- Van der Eycken, Erik (författare)
- KU Leuven, Belgium
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- Steenackers, Hans (författare)
- KU Leuven, Belgium
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(creator_code:org_t)
- 2018-12-13
- 2019
- Engelska.
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Ingår i: Journal of Biomedical Materials Research. Part B - Applied biomaterials. - : Wiley. - 1552-4973 .- 1552-4981. ; 107:6, s. 1908-1919
- Relaterad länk:
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https://lirias.kuleu...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Biofilms, especially those formed by Staphylococcus aureus, play a key role in the development of orthopedic implant infections. Eradication of these infections is challenging due to the elevated tolerance of biofilm cells against antimicrobial agents. In this study, we developed an antibiofilm coating consisting of 5-(4-bromophenyl)-N-cyclopentyl-1-octyl-1H-imidazol-2-amine, designated as LC0024, covalently bound to a titanium implant surface (LC0024-Ti). We showed in vitro that the LC0024-Ti surface reduces biofilm formation of S. aureus in a specific manner without reducing the planktonic cells above the biofilm, as evaluated by plate counting and fluorescence microscopy. The advantage of compounds that only inhibit biofilm formation without affecting the viability of the planktonic cells, is that reduced development of bacterial resistance is expected. To determine the antibiofilm activity of LC0024-Ti surfaces in vivo, a biomaterial-associated murine infection model was used. The results indicated a significant reduction in S. aureus biofilm formation (up to 96%) on the LC0024-Ti substrates compared to pristine titanium controls. Additionally, we found that the LC0024-Ti substrates did not affect the attachment and proliferation of human cells involved in osseointegration and bone repair. In summary, our results emphasize the clinical potential of covalent coatings of LC0024 on titanium implant surfaces to reduce the risk of orthopedic implant infections.
Nyckelord
- 5-aryl-2-aminoimidazole
- biofilm
- orthopedic implant
- Staphylococcus aureus
- titanium
- Antimicrobial agents
- Bacteria
- Biofilms
- Cells
- Coatings
- Cytology
- Fluorescence microscopy
- Bacterial resistance
- Biofilm formation
- Orthopedic implant infections
- Titanium implant surface
- Titanium surfaces
- Metal implants
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Peeters, Elien
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Hooyberghs, Geer ...
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Robijns, Stijn
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De Weerdt, Ami
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Kucharíková, Son ...
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Tournu, Helene
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visa fler...
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Braem, Annabel
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Čeh, Katerina
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Majdic, Gregor
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Španič, Tanja
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Pogorevc, Estera
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Claes, Birgit
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Dovgan, Barbara
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Girandon, Lenart
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Impellizzeri, Fr ...
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Erdtmann, Martin
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Krona, Annika
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Vleugels, Jef
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Fröhlich, Mirjan
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Garcia-Forgas, J ...
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De Brucker, Katr ...
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Cammue, Bruno
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Thevissen, Karin
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Van Dijck, Patri ...
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Vanderleyden, Jo ...
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Van der Eycken, ...
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Steenackers, Han ...
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Journal of Biome ...
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