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3D high spatial res...
3D high spatial resolution visualisation and quantification of interconnectivity in polymer films
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- Fager, Cecilia, 1990 (author)
- Chalmers University of Technology, Sweden,Chalmers tekniska högskola
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- Eriksson Barman, Sandra, 1985 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers University of Technology, Sweden
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- Röding, Magnus (author)
- RISE,Jordbruk och livsmedel,RISE Research Institutes of Sweden
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- Olsson, Anna, 1985 (author)
- AstraZeneca, Sweden,AstraZeneca AB
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- Loren, Niklas (author)
- RISE,Jordbruk och livsmedel,Chalmers University of Technology, Sweden,RISE Research Institutes of Sweden,Chalmers tekniska högskola
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- von Corswant, C. (author)
- AstraZeneca, Sweden,AstraZeneca AB
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- Bolin, David, 1983 (author)
- King Abdullah University of Science and Technology, Saudi Arabia,King Abdullah University of Science and Technology (KAUST)
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- Rootzen, Holger, 1945 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper,Department of Mathematical Sciences,Chalmers University of Technology, Sweden
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- Olsson, Eva, 1960 (author)
- Chalmers University of Technology, Sweden,Chalmers tekniska högskola
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(creator_code:org_t)
- Elsevier B.V. 2020
- 2020
- English.
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In: International Journal of Pharmaceutics. - : Elsevier B.V.. - 0378-5173 .- 1873-3476. ; 587
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Abstract
Subject headings
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- A porous network acts as transport paths for drugs through films for controlled drug release. The interconnectivity of the network strongly influences the transport properties. It is therefore important to quantify the interconnectivity and correlate it to transport properties for control and design of new films. This work presents a novel method for 3D visualisation and analysis of interconnectivity. High spatial resolution 3D data on porous polymer films for controlled drug release has been acquired using a focused ion beam (FIB) combined with a scanning electron microscope (SEM). The data analysis method enables visualisation of pore paths starting at a chosen inlet pore, dividing them into groups by length, enabling a more detailed quantification and visualisation. The method also enables identification of central features of the porous network by quantification of channels where pore paths coincide. The method was applied to FIB-SEM data of three leached ethyl cellulose (EC)/hydroxypropyl cellulose (HPC) films with different weight percentages. The results from the analysis were consistent with the experimentally measured release properties of the films. The interconnectivity and porosity increase with increasing amount of HPC. The bottleneck effect was strong in the leached film with lowest porosity.
Subject headings
- NATURVETENSKAP -- Kemi -- Polymerkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Polymer Chemistry (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Kemiteknik -- Polymerteknologi (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Chemical Engineering -- Polymer Technologies (hsv//eng)
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
- NATURVETENSKAP -- Matematik (hsv//swe)
- NATURAL SCIENCES -- Mathematics (hsv//eng)
Keyword
- 3D
- Bottlenecks
- Focused ion beam
- Geodesic channels
- Geodesic paths
- Interconnectivity
- Polymer
- Porosity
- Scanning electron microscopy
- Visualisation
- ethyl cellulose
- hydroxypropylcellulose
- porous polymer
- Article
- controlled drug release
- data visualization
- electron beam
- focused ion beam scanning electron microscopy tomography
- image segmentation
- priority journal
- quantitative analysis
- three-dimensional imaging
- Interconnectivity
- Visualisation
- 3D
- Porosity
- Polymer
- Focused ion
- beam
- Scanning electron microscopy
- Geodesic paths
- Geodesic channels
- Bottlenecks
- pore structure
- microstructure
- tomography
- cellulose
- permeability
- connectivity
- tortuosity
- diffusion
- paper
- Pharmacology & Pharmacy
Publication and Content Type
- ref (subject category)
- art (subject category)
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Fager, Cecilia, ...
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Eriksson Barman, ...
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Röding, Magnus
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Olsson, Anna, 19 ...
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Loren, Niklas
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von Corswant, C.
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Bolin, David, 19 ...
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Rootzen, Holger, ...
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Olsson, Eva, 196 ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Polymer Chemistr ...
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Chemical Enginee ...
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and Polymer Technolo ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Physical Science ...
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and Other Physics To ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Mathematics
- Articles in the publication
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International Jo ...
- By the university
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RISE
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Chalmers University of Technology
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University of Gothenburg