NiOX Template-Grown Ni-MOF-Coated Carbon Paper Electrode Embedded Extended Gate Field Effect Transistor for Glucose Detection in Saliva : En Route toward the Noninvasive Diagnosis of Diabetes Mellitus

• Our present work focuses on the development of nickel oxalate (NiOX) template-assisted growth of a nickel-metal organic framework (Ni-MOF) with sheetlike morphology on carbon paper (CP) electrode for the noninvasive detection of glucose. We have utilized an extended gate field effect transistor (EGFET) where the Ni-MOF/CP electrode serves as the extended gate of a commercial n-type metal oxide semiconductor FET for sensing glucose. The electrode detects glucose concentrations ranging from 20 μM to 1.47 mM. The sensor operates at a voltage of 0.7 V in the physiologically relevant electrolyte of phosphate-buffered saline (PBS) with a response time of less than 5 s. The sensitivity is calculated as 86 μA mM-1 cm-2 from the linear region of the sensor response to the glucose concentration (20 μM to 0.27 mM). Also, Ni-MOF/CP has shown a good selective response toward glucose against uric acid, sucrose, fructose, and ascorbic acid. Additionally, the glucose sensing mechanism is investigated through work function changes of the sensing electrode using a scanning Kelvin probe. Real-time sample testing has revealed that the sensor preserves the sensitivity in human saliva too. In summary, we conclude that the Ni-MOF/CP extended gate electrode EGFET is an alternative device for salivary glucose detection toward the noninvasive diagnosis of diabetes mellitus that can identify hyperglycemic, normal, and hypoglycemic conditions. 

Subject headings

NATURVETENSKAP  -- Kemi -- Materialkemi (hsv//swe)

NATURAL SCIENCES  -- Chemical Sciences -- Materials Chemistry (hsv//eng)

Keyword

diabetes mellitus

EGFET

nickel MOF on carbon paper

noninvasive glucose detection

saliva

scanning Kelvin probe

Carbon

Electrolytes

Field effect transistors

Glucose

Glucose sensors

MOS devices

Nickel compounds

Organometallics

Oxide semiconductors

Paper

Physiological models

Probes

Refractory metal compounds

Carbon paper

Extended-gate field-effect transistors

Glucose detection

Metalorganic frameworks (MOFs)

Non-invasive diagnosis

Scanning Kelvin probes

Electrodes

Publication and Content Type

ref (subject category)

art (subject category)